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F11 coagulation factor XI [ Rattus norvegicus (Norway rat) ]

Gene ID: 290757, updated on 13-Apr-2024

Summary

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Official Symbol
F11provided by RGD
Official Full Name
coagulation factor XIprovided by RGD
Primary source
RGD:1309364
See related
Ensembl:ENSRNOG00000013684 AllianceGenome:RGD:1309364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00086
Summary
Enables serine-type aminopeptidase activity. Involved in blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in factor XI deficiency and thrombosis. Orthologous to human F11 (coagulation factor XI). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 447.5) See more
Orthologs
human mouse all
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Genomic context

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Location:
16q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53720502..53741547)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46987988..47009015)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50179458..50201644)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B, pseudogene 9 Neighboring gene kallikrein B1 Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene melatonin receptor 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation. Samuel D, et al. Proc Natl Acad Sci U S A, 2007 Oct 2. PMID 17884987, Free PMC Article
  2. Crystal structure of the factor XI zymogen reveals a pathway for transactivation. Papagrigoriou E, et al. Nat Struct Mol Biol, 2006 Jun. PMID 16699514
  3. A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis. Espinola RG, et al. Am J Pathol, 2004 Sep. PMID 15331420, Free PMC Article
  4. Molecular genetic analysis of factor XI deficiency: identification of five novel gene alterations and the origin of type II mutation in Portuguese families. Ventura C, et al. Thromb Haemost, 2000 Nov. PMID 11127865
  5. High levels of coagulation factor XI as a risk factor for venous thrombosis. Meijers JC, et al. N Engl J Med, 2000 Mar 9. PMID 10706899

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coagulation factor XI
NP_001398595.1
XP_006253207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411666.1 → NP_001398595.1  coagulation factor XI precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Related
    ENSRNOP00000073061.2, ENSRNOT00000077662.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    53720502..53741547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253145.4 → XP_006253207.1  coagulation factor XI isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4I9
    Conserved Domains (4) summary
    smart00223
    Location:130 → 213
    APPLE; APPLE domain
    smart00020
    Location:317 → 545
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:318 → 545
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl00112
    Location:6 → 33
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047848.1: Suppressed sequence

    Description
    NM_001047848.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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