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Irf2 interferon regulatory factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290749, updated on 11-Apr-2024

Summary

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Official Symbol
Irf2provided by RGD
Official Full Name
interferon regulatory factor 2provided by RGD
Primary source
RGD:1304922
See related
Ensembl:ENSRNOG00000009824 AllianceGenome:RGD:1304922
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to virus; immune system process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; focal adhesion; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human IRF2 (interferon regulatory factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 139.1), Thymus (RPKM 112.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52171855..52283620, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45439215..45550054, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48582354..48732129, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482380 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3, pseudogene 1 Neighboring gene uncharacterized LOC102552290 Neighboring gene uncharacterized LOC134482504 Neighboring gene ubiquitin conjugating enzyme E2 V1, pseudogene 3 Neighboring gene uncharacterized LOC120097385 Neighboring gene uncharacterized LOC134482506 Neighboring gene ribosomal protein L4, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. Aziz F, et al. Mol Biol Rep, 1998 Jan. PMID 9540062
  2. A diverse range of gene products are effectors of the type I interferon antiviral response. Schoggins JW, et al. Nature, 2011 Apr 28. PMID 21478870, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon regulatory factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047086.1 → NP_001040551.1  interferon regulatory factor 2

    See identical proteins and their annotated locations for NP_001040551.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ674266
    UniProtKB/TrEMBL
    A0A0G2K1F1, A0A9K3Y6S1, Q0PXQ8
    Related
    ENSRNOP00000071815.2, ENSRNOT00000083632.2
    Conserved Domains (1) summary
    pfam00605
    Location:7 → 112
    IRF; Interferon regulatory factor transcription factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    52171855..52283620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275233.1 → XP_063131303.1  interferon regulatory factor 2 isoform X1

  2. XM_039094379.2 → XP_038950307.1  interferon regulatory factor 2 isoform X3

    Conserved Domains (1) summary
    pfam00605
    Location:2 → 74
    IRF; Interferon regulatory factor transcription factor

  3. XM_006253139.5 → XP_006253201.1  interferon regulatory factor 2 isoform X2

    See identical proteins and their annotated locations for XP_006253201.1

    UniProtKB/TrEMBL
    A0A0G2K1F1, A0A9K3Y6S1, Q0PXQ8
    Conserved Domains (1) summary
    pfam00605
    Location:7 → 112
    IRF; Interferon regulatory factor transcription factor

  4. XM_063275234.1 → XP_063131304.1  interferon regulatory factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K1F1, A0A9K3Y6S1, Q0PXQ8
Nucleotide Protein Strain
Heading Accession and Version

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