Pgls 6-phosphogluconolactonase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pglsprovided by RGD
Official Full Name: 6-phosphogluconolactonaseprovided by RGD
Primary source: RGD:1307001
See related: Ensembl:ENSRNOG00000018326 AllianceGenome:RGD:1307001
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 6-phosphogluconolactonase activity and monosaccharide binding activity. Involved in pentose-phosphate shunt, oxidative branch. Predicted to be active in cytoplasm. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 72.8), Adrenal (RPKM 70.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18334299..18339785)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18300317..18305803)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20020444..20025930)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH132813 (e-PCR)
- UniSTS:216096

BE099440 (e-PCR)
- UniSTS:245663

RH131434 (e-PCR)
- UniSTS:214717

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 6-phosphogluconolactonase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphogluconolactonase activity	IDA Inferred from Direct Assay more info	PubMed
enables 6-phosphogluconolactonase activity	IEA Inferred from Electronic Annotation more info
enables 6-phosphogluconolactonase activity	ISO Inferred from Sequence Orthology more info
enables monosaccharide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 6-phosphogluconolactonase

Names: 6PGL

NP_001099536.1

EC 3.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.