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Cr2 complement C3d receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289395, updated on 13-Apr-2024

Summary

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Official Symbol
Cr2provided by RGD
Official Full Name
complement C3d receptor 2provided by RGD
Primary source
RGD:1310065
See related
Ensembl:ENSRNOG00000034164 AllianceGenome:RGD:1310065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cd21
Summary
Predicted to enable several functions, including complement binding activity; complement receptor activity; and protein homodimerization activity. Predicted to be involved in B cell differentiation; B cell proliferation; and negative regulation of complement activation, classical pathway. Predicted to act upstream of or within with a negative effect on complement activation, alternative pathway. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in several cellular components, including cell surface; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in common variable immunodeficiency; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 1089.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
13q27
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (109207034..109244980, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (106678579..106716595, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (113890274..113927824, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene CD46 molecule Neighboring gene uncharacterized LOC108352604 Neighboring gene complement C3b/C4b receptor 1 like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120096211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents. Wu ML, et al. Int Immunopharmacol, 2023 Jan. PMID 36527877
  2. Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. Kane SJ, et al. mSphere, 2017 Nov-Dec. PMID 29202042, Free PMC Article
  3. Complement and natural antibody are required in the long-term memory response to influenza virus. Fernandez Gonzalez S, et al. Vaccine, 2008 Dec 30. PMID 19388171
  4. Characterization of C3 receptors on cultured rat glomerular endothelial cells. Alexander JJ, et al. Kidney Int, 1997 Apr. PMID 9083278
  5. In vivo decrease in the expression of complement receptor 2 on B-cells in HIV infection. Scott ME, et al. AIDS, 1993 Jan. PMID 8442917

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents.
    Title: Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents.
  2. CD21 is expressed in the rat mucosal mast cell line RBL-2H3
    Title: Mucosal type mast cells express complement receptor type 2 (CD21).
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables complement binding ISO
Inferred from Sequence Orthology
more info
  
enables complement receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect complement activation, alternative pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in complement activation, alternative pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in complement receptor mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement receptor type 2
Names
complement component (3d/Epstein Barr virus) receptor 2
complement component 3d receptor 2
complement receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105989.2 → NP_001099459.2  complement receptor type 2 precursor

    See identical proteins and their annotated locations for NP_001099459.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JH50
    Conserved Domains (2) summary
    cd00033
    Location:719 → 775
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:711 → 964
    PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    109207034..109244980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769847.4 → XP_008768069.1  complement receptor type 2 isoform X1

    UniProtKB/TrEMBL
    D3Z9F7
    Related
    ENSRNOP00000010910.7
    Conserved Domains (4) summary
    cd00033
    Location:1096 → 1152
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:83 → 140
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:10 → 274
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:337 → 395
    Sushi; Sushi repeat (SCR repeat)

  2. XM_063272195.1 → XP_063128265.1  complement receptor type 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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