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Ppox protoporphyrinogen oxidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 289219, updated on 11-Apr-2024

Summary

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Official Symbol
Ppoxprovided by RGD
Official Full Name
protoporphyrinogen oxidaseprovided by RGD
Primary source
RGD:1310543
See related
Ensembl:ENSRNOG00000003567 AllianceGenome:RGD:1310543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to xenobiotic stimulus. Located in mitochondrion. Is integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 112.8), Liver (RPKM 73.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86230111..86235028, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83697661..83701998, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89650094..89654998, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 4 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene G protein subunit gamma 5, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Herbicide-induced experimental variegate porphyria in mice: tissue porphyrinogen accumulation and response to porphyrogenic drugs. Krijt J, et al. Can J Physiol Pharmacol, 1997 Oct-Nov. PMID 9431441
  2. Variegate porphyria in South Africa, 1688-1996--new developments in an old disease. Hift RJ, et al. S Afr Med J, 1997 Jun. PMID 9254745
  3. Rat liver protoporphyrinogen IX oxidase: site of synthesis and factor influencing its activity. Kolarov J, et al. Biochem Biophys Res Commun, 1983 Oct 31. PMID 6316951
  4. An h.p.l.c. assay for protoporphyrinogen oxidase activity in rat liver. Li F, et al. Biochem J, 1987 May 1. PMID 3663105, Free PMC Article
  5. A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Medlock AE, et al. Cell Mol Biol (Noisy-le-grand), 2002 Feb. PMID 11929050

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxygen-dependent protoporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen-dependent protoporphyrinogen oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen-dependent protoporphyrinogen oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables primary amine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme B biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in porphyrin-containing compound biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in porphyrin-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protoporphyrinogen oxidase
NP_001099438.1
XP_006250302.1
XP_006250303.1
XP_006250305.1
XP_038946434.1
XP_038946436.1
XP_038946437.1
XP_063128198.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105968.1 → NP_001099438.1  protoporphyrinogen oxidase

    See identical proteins and their annotated locations for NP_001099438.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473985
    UniProtKB/TrEMBL
    A6JFW5
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 471
    proto_IX_ox; protoporphyrinogen oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    86230111..86235028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090506.2 → XP_038946434.1  protoporphyrinogen oxidase isoform X2

    UniProtKB/TrEMBL
    A6JFW5
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 471
    proto_IX_ox; protoporphyrinogen oxidase

  2. XM_006250240.5 → XP_006250302.1  protoporphyrinogen oxidase isoform X1

    See identical proteins and their annotated locations for XP_006250302.1

    UniProtKB/TrEMBL
    D3ZVN7
    Conserved Domains (3) summary
    TIGR00562
    Location:3 → 482
    proto_IX_ox; protoporphyrinogen oxidase
    pfam13450
    Location:7 → 65
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:238 → 372
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_006250241.4 → XP_006250303.1  protoporphyrinogen oxidase isoform X1

    See identical proteins and their annotated locations for XP_006250303.1

    UniProtKB/TrEMBL
    D3ZVN7
    Related
    ENSRNOP00000004896.5
    Conserved Domains (3) summary
    TIGR00562
    Location:3 → 482
    proto_IX_ox; protoporphyrinogen oxidase
    pfam13450
    Location:7 → 65
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:238 → 372
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_006250243.3 → XP_006250305.1  protoporphyrinogen oxidase isoform X3

    Conserved Domains (2) summary
    TIGR00562
    Location:18 → 427
    proto_IX_ox; protoporphyrinogen oxidase
    cl21454
    Location:183 → 317
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. XM_039090508.2 → XP_038946436.1  protoporphyrinogen oxidase isoform X4

    Conserved Domains (1) summary
    TIGR00562
    Location:45 → 350
    proto_IX_ox; protoporphyrinogen oxidase

  6. XM_063272128.1 → XP_063128198.1  protoporphyrinogen oxidase isoform X4

  7. XM_039090509.2 → XP_038946437.1  protoporphyrinogen oxidase isoform X5

    Conserved Domains (1) summary
    COG1232
    Location:5 → 299
    HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version

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