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Mmp17 matrix metallopeptidase 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288626, updated on 5-Mar-2024

Summary

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Official Symbol
Mmp17provided by RGD
Official Full Name
matrix metallopeptidase 17provided by RGD
Primary source
RGD:1311541
See related
Ensembl:ENSRNOG00000023643 AllianceGenome:RGD:1311541
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within drinking behavior and kidney development. Predicted to be located in extracellular matrix. Orthologous to human MMP17 (matrix metallopeptidase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 73.6), Uterus (RPKM 27.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32710504..32735418, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27074398..27099317, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30701900..30728683, complement) , (30353874..30356526, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene zinc finger protein 11 Neighboring gene uncharacterized LOC120095935 Neighboring gene splicing factor SWAP Neighboring gene uncharacterized LOC134481178 Neighboring gene uncharacterized LOC102555340

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment. Wang X, et al. J Exp Med, 2014 Nov 17. PMID 25348153, Free PMC Article
  2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within drinking behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-17
Names
matrix metalloproteinase 17
NP_001099395.1
XP_063127237.1
XP_063127238.1
XP_063127239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105925.1 → NP_001099395.1  matrix metalloproteinase-17 precursor

    See identical proteins and their annotated locations for NP_001099395.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6J0R3, D3ZXJ0
    Related
    ENSRNOP00000037549.4, ENSRNOT00000035881.6
    Conserved Domains (4) summary
    cd00094
    Location:333 → 527
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:131 → 294
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:131 → 294
    Peptidase_M10; Matrixin
    pfam01471
    Location:44 → 104
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    32710504..32735418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271167.1 → XP_063127237.1  matrix metalloproteinase-17 isoform X1

  2. XM_063271169.1 → XP_063127239.1  matrix metalloproteinase-17 isoform X3

  3. XM_063271168.1 → XP_063127238.1  matrix metalloproteinase-17 isoform X2

RNA

  1. XR_010056375.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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