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Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288480, updated on 5-Mar-2024

Summary

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Official Symbol
Aimp2provided by RGD
Official Full Name
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2provided by RGD
Primary source
RGD:1560787
See related
Ensembl:ENSRNOG00000001044 AllianceGenome:RGD:1560787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Jtv1
Summary
Predicted to enable molecular adaptor activity. Acts upstream of or within positive regulation of neuron death. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 220.6), Heart (RPKM 126.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15814854..15824432)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10701194..10710772)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12738784..12748345)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B Neighboring gene small nucleolar RNA SNORA51 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Ko HS, et al. Proc Natl Acad Sci U S A, 2010 Sep 21. PMID 20823226, Free PMC Article
  2. LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Yannay-Cohen N, et al. Mol Cell, 2009 Jun 12. PMID 19524539
  3. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Kim MJ, et al. Nat Genet, 2003 Jul. PMID 12819782
  4. Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells. Kaminska M, et al. J Biol Chem, 2009 May 15. PMID 19289464, Free PMC Article
  5. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. Kaminska M, et al. J Biol Chem, 2009 Mar 6. PMID 19131329

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125271

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within type II pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Names
JTV1
multisynthase complex auxiliary component p38
multisynthetase complex auxiliary component p38
protein JTV-1
rCG42778-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037348.1 → NP_001032425.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2

    See identical proteins and their annotated locations for NP_001032425.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107947
    UniProtKB/Swiss-Prot
    Q32PX2
    UniProtKB/TrEMBL
    A0A8L2PZG3
    Related
    ENSRNOP00000001379.3, ENSRNOT00000001379.6
    Conserved Domains (2) summary
    cd03200
    Location:214 → 309
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam16780
    Location:1 → 33
    AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15814854..15824432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248863.5 → XP_006248925.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2PZG3
    Conserved Domains (1) summary
    cd03200
    Location:174 → 269
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32PX2.1 GenPept UniProtKB/Swiss-Prot:Q32PX2

Gene LinkOut

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