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Ifnar1 interferon alpha and beta receptor subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288264, updated on 13-Apr-2024

Summary

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Official Symbol
Ifnar1provided by RGD
Official Full Name
interferon alpha and beta receptor subunit 1provided by RGD
Primary source
RGD:1305399
See related
Ensembl:ENSRNOG00000028594 AllianceGenome:RGD:1305399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable type I interferon binding activity and type I interferon receptor activity. Involved in cytokine-mediated signaling pathway. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 331.9), Spleen (RPKM 237.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ifnar1 in Genome Data Viewer
Location:
11q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44211769..44238206)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30725774..30752227)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31640407..31666839)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095617 Neighboring gene uncharacterized LOC120095616 Neighboring gene uncharacterized LOC102554317 Neighboring gene small ribosomal subunit protein eS7-like Neighboring gene uncharacterized LOC134481058 Neighboring gene interferon gamma receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A. Martin FJ, et al. J Clin Invest, 2009 Jul. PMID 19603548, Free PMC Article
  2. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Qaisar N, et al. Diabetes, 2017 Jan. PMID 27999109, Free PMC Article
  3. Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1. Datta S, et al. Virol J, 2011 Jul 14. PMID 21756311, Free PMC Article
  4. Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice. Seo SU, et al. PLoS Pathog, 2011 Feb. PMID 21383977, Free PMC Article
  5. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. Shahangian A, et al. J Clin Invest, 2009 Jul. PMID 19487810, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables JAK pathway signal transduction adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
  
enables interferon receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables type I interferon binding ISO
Inferred from Sequence Orthology
more info
  
enables type I interferon receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type I interferon receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon alpha/beta receptor 1
Names
interferon (alpha and beta) receptor 1
interferon (alpha, beta and omega) receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105893.1 → NP_001099363.2  interferon alpha/beta receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001099363.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6JLF6, D3ZDS9
    Related
    ENSRNOP00000031611.5, ENSRNOT00000029985.7
    Conserved Domains (2) summary
    pfam09294
    Location:126 → 223
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:29 → 114
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001271316.1 → NP_001258245.1  interferon alpha/beta receptor 1 isoform 2

    See identical proteins and their annotated locations for NP_001258245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional exon, compared to variant 1. This difference causes translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A0G2JXD8, A6JLF8
    Related
    ENSRNOP00000070232.1, ENSRNOT00000091472.2
    Conserved Domains (1) summary
    cl21522
    Location:175 → 271
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    44211769..44238206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270427.1 → XP_063126497.1  interferon alpha/beta receptor 1 isoform X1

  2. XM_063270428.1 → XP_063126498.1  interferon alpha/beta receptor 1 isoform X3

  3. XM_039088212.2 → XP_038944140.1  interferon alpha/beta receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AH72
    Related
    ENSRNOP00000092520.1
    Conserved Domains (2) summary
    pfam09294
    Location:115 → 212
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:18 → 103
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_017597942.2 → XP_017453431.1  interferon alpha/beta receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JXD8, A6JLF8
    Conserved Domains (1) summary
    cl21522
    Location:175 → 271
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_063270429.1 → XP_063126499.1  interferon alpha/beta receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JXD8, A6JLF8
Nucleotide Protein Strain
Heading Accession and Version

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