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Hcls1 hematopoietic cell specific Lyn substrate 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288077, updated on 11-Apr-2024

Summary

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Symbol
Hcls1provided by RGD
Full Name
hematopoietic cell specific Lyn substrate 1provided by RGD
Primary source
RGD:1304754
See related
Ensembl:ENSRNOG00000038881 AllianceGenome:RGD:1304754
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including SH3 domain binding activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of myeloid leukocyte differentiation; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in cortical actin cytoskeleton; plasma membrane; and site of polarized growth. Predicted to colocalize with actin filament. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 404.4), Thymus (RPKM 366.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77322873..77346333, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63817482..63840943, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66736966..66759402, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase theta Neighboring gene G protein subunit gamma 10, pseudogene 1 Neighboring gene F-box protein 40 Neighboring gene golgin B1 Neighboring gene IQ motif containing B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. Ingley E, et al. J Biol Chem, 2000 Mar 17. PMID 10713104
  2. Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins. Yamabhai M, et al. Anal Biochem, 1997 Apr 5. PMID 9126384
  3. Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Skokowa J, et al. Nat Med, 2012 Oct. PMID 23001182, Free PMC Article
  4. Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Samuels AL, et al. Blood, 2009 Apr 16. PMID 19064729
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in granulocyte colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of leukocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hematopoietic lineage cell-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011898.1 → NP_001011898.1  hematopoietic lineage cell-specific protein

    See identical proteins and their annotated locations for NP_001011898.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079081
    UniProtKB/TrEMBL
    F7F5Q9, Q68FX4
    Related
    ENSRNOP00000003326.5, ENSRNOT00000003326.6
    Conserved Domains (3) summary
    PRK00404
    Location:263 → 353
    tatB; Sec-independent protein translocase subunit TatB
    pfam02218
    Location:119 → 154
    HS1_rep; Repeat in HS1/Cortactin
    cl17036
    Location:425 → 476
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    77322873..77346333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088123.2 → XP_038944051.1  hematopoietic lineage cell-specific protein isoform X1

    UniProtKB/TrEMBL
    F7F5Q9, Q68FX4
    Conserved Domains (3) summary
    PRK00404
    Location:263 → 353
    tatB; Sec-independent protein translocase subunit TatB
    pfam02218
    Location:119 → 154
    HS1_rep; Repeat in HS1/Cortactin
    cl17036
    Location:425 → 476
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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