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Eif4g1 eukaryotic translation initiation factor 4 gamma 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287986, updated on 13-Apr-2024

Summary

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Official Symbol
Eif4g1provided by RGD
Official Full Name
eukaryotic translation initiation factor 4 gamma 1provided by RGD
Primary source
RGD:1306144
See related
Ensembl:ENSRNOG00000001738 AllianceGenome:RGD:1306144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables eukaryotic initiation factor 4E binding activity. Involved in lung development and response to ethanol. Part of eukaryotic translation initiation factor 4F complex. Is active in postsynapse. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 862.7), Heart (RPKM 764.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q23
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93726322..93746387, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80221919..80241958, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83907659..83927683, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit H Neighboring gene chloride voltage-gated channel 2 Neighboring gene family with sequence similarity 131, member A Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 2 Neighboring gene uncharacterized LOC102551589 Neighboring gene endothelin-converting enzyme 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex. Akabayov SR, et al. Biochemistry, 2014 Oct 21. PMID 25255371, Free PMC Article
  2. Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death. Vosler PS, et al. Proc Natl Acad Sci U S A, 2011 Nov 1. PMID 22006312, Free PMC Article
  3. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Hoeffer CA, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21289279, Free PMC Article
  4. Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis. Vary TC, et al. Shock, 2006 Dec. PMID 17117141
  5. Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Bellsolell L, et al. Structure, 2006 May. PMID 16698552

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrate that calpain-mediated degradation of a translation initiation factor, eIF4G1, is a cause of both persistent PSI and neuronal death
    Title: Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death.
  2. At birth increased Po(2) acts with glucocorticosteroid through an mTOR-related pathway to increase alpha-ENaC protein synthesis, thereby promoting lung fluid absorption.
    Title: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
  3. the eIF4E-eIF4G complex is more stringently required for plasticity induced by initial learning than for that triggered by reactivation of an existing memory.
    Title: Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation.
  4. eIF4E-eIF4G association and phosphorylation of 4E-BP1 and GSK-3 are increased after HFES in adult, but not in aged, animals.
    Title: Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle.
  5. IL-1 is the proinflammatory mediator responsible for the reduced level of phosphorylated eIF4G
    Title: Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables eukaryotic initiation factor 4E binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables eukaryotic initiation factor 4E binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation factor activity, RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in lung development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in macromolecule biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell periphery ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in translation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 4F complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4 gamma 1
Names
eukaryotic translation initiation factor 4 gamma 1-like
voltage-dependent P/Q-type calcium channel subunit alpha-1A-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427476.1 → NP_001414405.1  eukaryotic translation initiation factor 4 gamma 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    93726322..93746387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270353.1 → XP_063126423.1  eukaryotic translation initiation factor 4 gamma 1 isoform X14

  2. XM_063270352.1 → XP_063126422.1  eukaryotic translation initiation factor 4 gamma 1 isoform X13

  3. XM_063270350.1 → XP_063126420.1  eukaryotic translation initiation factor 4 gamma 1 isoform X12

  4. XM_063270348.1 → XP_063126418.1  eukaryotic translation initiation factor 4 gamma 1 isoform X11

  5. XM_063270346.1 → XP_063126416.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

  6. XM_063270343.1 → XP_063126413.1  eukaryotic translation initiation factor 4 gamma 1 isoform X8

  7. XM_006248584.5 → XP_006248646.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

    See identical proteins and their annotated locations for XP_006248646.1

    UniProtKB/TrEMBL
    D4AD15
    Conserved Domains (3) summary
    cd11559
    Location:1433 → 1562
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1234 → 1346
    MA3; MA3 domain
    pfam02854
    Location:757 → 985
    MIF4G; MIF4G domain

  8. XM_063270355.1 → XP_063126425.1  eukaryotic translation initiation factor 4 gamma 1 isoform X15

  9. XM_063270347.1 → XP_063126417.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

  10. XM_063270344.1 → XP_063126414.1  eukaryotic translation initiation factor 4 gamma 1 isoform X8

  11. XM_063270354.1 → XP_063126424.1  eukaryotic translation initiation factor 4 gamma 1 isoform X14

  12. XM_063270351.1 → XP_063126421.1  eukaryotic translation initiation factor 4 gamma 1 isoform X13

  13. XM_063270340.1 → XP_063126410.1  eukaryotic translation initiation factor 4 gamma 1 isoform X6

  14. XM_006248585.5 → XP_006248647.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

    See identical proteins and their annotated locations for XP_006248647.1

    UniProtKB/TrEMBL
    D4AD15
    Conserved Domains (3) summary
    cd11559
    Location:1433 → 1562
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1234 → 1346
    MA3; MA3 domain
    pfam02854
    Location:757 → 985
    MIF4G; MIF4G domain

  15. XM_006248581.5 → XP_006248643.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

    See identical proteins and their annotated locations for XP_006248643.1

    UniProtKB/TrEMBL
    M0RD03
    Conserved Domains (3) summary
    cd11559
    Location:1440 → 1569
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1241 → 1353
    MA3; MA3 domain
    pfam02854
    Location:764 → 992
    MIF4G; MIF4G domain

  16. XM_017598182.3 → XP_017453671.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

    UniProtKB/TrEMBL
    M0RD03
    Conserved Domains (3) summary
    cd11559
    Location:1440 → 1569
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1241 → 1353
    MA3; MA3 domain
    pfam02854
    Location:764 → 992
    MIF4G; MIF4G domain

  17. XM_063270341.1 → XP_063126411.1  eukaryotic translation initiation factor 4 gamma 1 isoform X6

  18. XM_063270339.1 → XP_063126409.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

  19. XM_063270349.1 → XP_063126419.1  eukaryotic translation initiation factor 4 gamma 1 isoform X11

  20. XM_063270345.1 → XP_063126415.1  eukaryotic translation initiation factor 4 gamma 1 isoform X9

  21. XM_063270342.1 → XP_063126412.1  eukaryotic translation initiation factor 4 gamma 1 isoform X7

  22. XM_063270338.1 → XP_063126408.1  eukaryotic translation initiation factor 4 gamma 1 isoform X4

  23. XM_063270336.1 → XP_063126406.1  eukaryotic translation initiation factor 4 gamma 1 isoform X2

    UniProtKB/TrEMBL
    D3ZU13

  24. XM_063270337.1 → XP_063126407.1  eukaryotic translation initiation factor 4 gamma 1 isoform X3

  25. XM_017598183.2 → XP_017453672.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

    UniProtKB/TrEMBL
    M0RD03
    Conserved Domains (3) summary
    cd11559
    Location:1440 → 1569
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1241 → 1353
    MA3; MA3 domain
    pfam02854
    Location:764 → 992
    MIF4G; MIF4G domain

  26. XM_063270358.1 → XP_063126428.1  eukaryotic translation initiation factor 4 gamma 1 isoform X18

  27. XM_063270360.1 → XP_063126430.1  eukaryotic translation initiation factor 4 gamma 1 isoform X19

  28. XM_063270356.1 → XP_063126426.1  eukaryotic translation initiation factor 4 gamma 1 isoform X16

  29. XM_063270357.1 → XP_063126427.1  eukaryotic translation initiation factor 4 gamma 1 isoform X17

Nucleotide Protein Strain
Heading Accession and Version

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