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Gprc5c G protein-coupled receptor, class C, group 5, member C [ Rattus norvegicus (Norway rat) ]

Gene ID: 287805, updated on 30-Mar-2024

Summary

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Official Symbol
Gprc5cprovided by RGD
Official Full Name
G protein-coupled receptor, class C, group 5, member Cprovided by RGD
Primary source
RGD:1311408
See related
Ensembl:ENSRNOG00000003144 AllianceGenome:RGD:1311408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and activation of protein kinase activity. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in extracellular exosome; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human GPRC5C (G protein-coupled receptor class C group 5 member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 230.0), Liver (RPKM 74.3) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100385682..100407953)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (99886900..99908928)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103395222..103417360)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 19 Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene Cd300a molecule Neighboring gene CD300 molecule-like family member b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article
  2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G-protein coupled receptor family C group 5 member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191591.2 → NP_001178520.2  G-protein coupled receptor family C group 5 member C precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K9B8, A0A8I5ZNK1
    Related
    ENSRNOP00000074938.2, ENSRNOT00000086924.2
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    100385682..100407953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247678.5 → XP_006247740.2  G-protein coupled receptor family C group 5 member C isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNK1, F1LRW5
    Related
    ENSRNOP00000004256.6
    Conserved Domains (1) summary
    cd15277
    Location:144 → 401
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  2. XM_006247682.4 → XP_006247744.2  G-protein coupled receptor family C group 5 member C isoform X2

    UniProtKB/Swiss-Prot
    Q3KRC4
    UniProtKB/TrEMBL
    A0A8I5ZNK1, B6ID02
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  3. XM_017597153.3 → XP_017452642.2  G-protein coupled receptor family C group 5 member C isoform X2

    UniProtKB/Swiss-Prot
    Q3KRC4
    UniProtKB/TrEMBL
    A0A8I5ZNK1, B6ID02
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  4. XM_006247681.5 → XP_006247743.2  G-protein coupled receptor family C group 5 member C isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZNK1, A0A8I6ATM9
    Related
    ENSRNOP00000095514.1
    Conserved Domains (1) summary
    cd15277
    Location:70 → 327
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  5. XM_006247685.5 → XP_006247747.2  G-protein coupled receptor family C group 5 member C isoform X2

    UniProtKB/Swiss-Prot
    Q3KRC4
    UniProtKB/TrEMBL
    A0A8I5ZNK1, B6ID02
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KRC4.2 GenPept UniProtKB/Swiss-Prot:Q3KRC4

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