Ccr7 C-C motif chemokine receptor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccr7provided by RGD
Official Full Name: C-C motif chemokine receptor 7provided by RGD
Primary source: RGD:735151
See related: Ensembl:ENSRNOG00000010665 AllianceGenome:RGD:735151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including positive regulation of immune response; positive regulation of leukocyte chemotaxis; and regulation of cytokine production. Predicted to act upstream of or within chemotaxis and homeostasis of number of cells. Predicted to be located in cell surface; mitochondrion; and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CCR7 (C-C motif chemokine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 203.1), Spleen (RPKM 150.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (84594399..84604514, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (84098193..84108309, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (87057335..87067444, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study shows induction of renal CCR7 expression in the Model of Anti-Thy1.1 Mesangioproliferative Glomerulonephritis in rat.
Title: CCR7 Is Important for Mesangial Cell Physiology and Repair.
These results suggest that upregulation of rat CCR7 expression does not change the phenotype, differentiation, or proliferation capacity of human adipose-derived stem cells (hASCs), but does enable efficient migration of hASCs to rat secondary lymphoid organs.
Title: Upregulation of CC Chemokine Receptor 7 (CCR7) Enables Migration of Xenogeneic Human Adipose-Derived Mesenchymal Stem Cells to Rat Secondary Lymphoid Organs.
CCL19/CCR7 contributes to the migration of bone marrow mesenchymal stem cells by upregulating MMP9 potentially via the PI3K/Akt pathway.
Title: Matrix metalloproteinase-9 is up-regulated by CCL19/CCR7 interaction via PI3K/Akt pathway and is involved in CCL19-driven BMSCs migration.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135124 (e-PCR)
- UniSTS:218401

PMC321570P11 (e-PCR)
- UniSTS:273114

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables C-C motif chemokine 19 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C motif chemokine 19 receptor activity	ISO Inferred from Sequence Orthology more info
enables C-C motif chemokine 21 receptor activity	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 19 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 19 binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 21 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 21 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in chemokine (C-C motif) ligand 19 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemokine (C-C motif) ligand 21 signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mature conventional dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hypersensitivity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor type 7

Names: chemokine (C-C motif) receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.