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Psmd3 proteasome 26S subunit, non-ATPase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287670, updated on 5-Mar-2024

Summary

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Official Symbol
Psmd3provided by RGD
Official Full Name
proteasome 26S subunit, non-ATPase 3provided by RGD
Primary source
RGD:1311470
See related
Ensembl:ENSRNOG00000028103 AllianceGenome:RGD:1311470
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 186.5), Kidney (RPKM 183.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84139249..84151879)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83643473..83655620)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86599007..86611180)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 3C Neighboring gene gasdermin A Neighboring gene small nucleolar RNA SNORD124 Neighboring gene colony stimulating factor 3 Neighboring gene mediator complex subunit 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
  2. Phosphorylation of ATPase subunits of the 26S proteasome. Mason GG, et al. FEBS Lett, 1998 Jul 3. PMID 9688553
  3. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
  4. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article
  5. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94658

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of proteasome accessory complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 3
Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
proteasome 26S non-ATPase subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008281.1 → NP_001008282.1  26S proteasome non-ATPase regulatory subunit 3

    See identical proteins and their annotated locations for NP_001008282.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085881
    UniProtKB/TrEMBL
    A6HIT6, F7EYU0, Q5U2S7
    Related
    ENSRNOP00000037928.3, ENSRNOT00000039836.5
    Conserved Domains (2) summary
    pfam01399
    Location:354 → 458
    PCI; PCI domain
    pfam08375
    Location:461 → 519
    Rpn3_C; Proteasome regulatory subunit C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    84139249..84151879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247272.4 → XP_006247334.1  26S proteasome non-ATPase regulatory subunit 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNE7
    Related
    ENSRNOP00000079824.1
    Conserved Domains (2) summary
    pfam01399
    Location:354 → 458
    PCI; PCI domain
    pfam08375
    Location:461 → 505
    Rpn3_C; Proteasome regulatory subunit C-terminal
Nucleotide Protein Strain
Heading Accession and Version

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