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Serpinf2 serpin family F member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287527, updated on 4-Jan-2025

Summary

Official Symbol
Serpinf2provided by RGD
Official Full Name
serpin family F member 2provided by RGD
Primary source
RGD:1306692
See related
EnsemblRapid:ENSRNOG00000003233 AllianceGenome:RGD:1306692
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of fibrinolysis. Located in extracellular space. Used to study acute necrotizing pancreatitis. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 2139.8) and Kidney (RPKM 538.2) See more
Orthologs
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Genomic context

See Serpinf2 in Genome Data Viewer
Location:
10q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60770698..60778782, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60272400..60280506, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62264247..62272353, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 4 Neighboring gene ribosomal protein L37, pseudogene 4 Neighboring gene serpin family F member 1 Neighboring gene WD repeat domain 81 Neighboring gene microRNA 6326

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in blood vessel morphogenesis  
involved_in collagen fibril organization  
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin  
involved_in negative regulation of endopeptidase activity  
involved_in negative regulation of fibrinolysis PubMed 
involved_in negative regulation of fibrinolysis  
involved_in negative regulation of plasminogen activation  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of JNK cascade  
involved_in positive regulation of cell differentiation  
involved_in positive regulation of collagen biosynthetic process  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of stress fiber assembly  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transforming growth factor beta production  
Component Evidence Code Pubs
located_in cell surface  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
part_of fibrinogen complex  

General protein information

Preferred Names
alpha-2-antiplasmin
Names
serine (or cysteine) peptidase inhibitor, clade F, member 2
serine (or cysteine) proteinase inhibitor, clade F, member 2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011892.1NP_001011892.1  alpha-2-antiplasmin precursor

    See identical proteins and their annotated locations for NP_001011892.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079362
    UniProtKB/TrEMBL
    F7FHF3, Q68FT8
    Related
    ENSRNOP00000004322.6, ENSRNOT00000004322.8
    Conserved Domains (1) summary
    cd02053
    Location:82433
    alpha2AP; Alpha2-antiplasmin (alpha2AP) is the primary inhibitor of plasmin, a proteinase that digests fibrin, the main component of blood clots. Alpha2-Antiplasmin forms an inactive 1 : 1 stoichiometric complex with plasmin. It also rapidly crosslinks to fibrin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    60770698..60778782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597114.2XP_017452603.1  alpha-2-antiplasmin isoform X1

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