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Eif4a1 eukaryotic translation initiation factor 4A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287436, updated on 13-Apr-2024

Summary

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Official Symbol
Eif4a1provided by RGD
Official Full Name
eukaryotic translation initiation factor 4A1provided by RGD
Primary source
RGD:735141
See related
Ensembl:ENSRNOG00000030628 AllianceGenome:RGD:735141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 1843.3), Spleen (RPKM 1273.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif4a1 in Genome Data Viewer
Location:
10q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54883093..54888602, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54384345..54389855, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56271257..56276764, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 15 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene Cd68 molecule Neighboring gene small nucleolar RNA SNORA48 Neighboring gene small nucleolar RNA, C/D box 10 Neighboring gene eukaryotic translation initiation factor 4A1 like Neighboring gene SUMO specific peptidase 3 Neighboring gene TNF superfamily member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI. Hashimoto K, et al. PLoS One, 2010 Nov 8. PMID 21151481, Free PMC Article
  2. Selective translational control and nonspecific posttranscriptional regulation of ribosomal protein gene expression during development and regeneration of rat liver. Aloni R, et al. Mol Cell Biol, 1992 May. PMID 1373810, Free PMC Article
  3. The diverse roles of the eIF4A family: you are the company you keep. Lu WT, et al. Biochem Soc Trans, 2014 Feb. PMID 24450646
  4. Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A. Nielsen PJ, et al. Nucleic Acids Res, 1985 Oct 11. PMID 3840589, Free PMC Article
  5. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest that eIF4AI might play a role in the novel mechanism of minocycline.
    Title: A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic initiation factor 4A-I
Names
eukaryotic translation initiation factor 4A
NP_955404.1
XP_006246686.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199372.3 → NP_955404.1  eukaryotic initiation factor 4A-I

    See identical proteins and their annotated locations for NP_955404.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A0E5, A6HFS9, Q6P3V8
    Related
    ENSRNOP00000086003.1, ENSRNOT00000100375.1
    Conserved Domains (1) summary
    PTZ00424
    Location:20 → 406
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54883093..54888602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246624.5 → XP_006246686.1  eukaryotic initiation factor 4A-I isoform X1

    UniProtKB/TrEMBL
    A6HFS9, F7F7A6
    Related
    ENSRNOP00000049419.2
    Conserved Domains (3) summary
    PTZ00424
    Location:25 → 411
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:251 → 366
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:39 → 240
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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