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Cops3 COP9 signalosome subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287367, updated on 5-Mar-2024

Summary

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Official Symbol
Cops3provided by RGD
Official Full Name
COP9 signalosome subunit 3provided by RGD
Primary source
RGD:1303002
See related
Ensembl:ENSRNOG00000053943 AllianceGenome:RGD:1303002
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein deneddylation and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 480.7), Heart (RPKM 340.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45117664..45151868, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44618115..44652807, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46182680..46206083, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene folliculin Neighboring gene dCTP pyrophosphatase 1, pseudogene 1 Neighboring gene U1 spliceosomal RNA Neighboring gene 5',3'-nucleotidase, mitochondrial Neighboring gene mediator complex subunit 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Yan J, et al. Mol Cell Biol, 2003 Oct. PMID 12972600, Free PMC Article
  2. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Sharon M, et al. Structure, 2009 Jan 14. PMID 19141280
  3. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Wei N, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707402
  4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94156

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 3
Names
COP9 (constitutive photomorphogenic) homolog, subunit 3
SGN3
signalosome subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004200.1 → NP_001004200.1  COP9 signalosome complex subunit 3

    See identical proteins and their annotated locations for NP_001004200.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079143
    UniProtKB/Swiss-Prot
    Q68FW9
    UniProtKB/TrEMBL
    A0A8I5Y8F4
    Related
    ENSRNOP00000069208.1, ENSRNOT00000091471.2
    Conserved Domains (1) summary
    pfam01399
    Location:259 → 362
    PCI; PCI domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    45117664..45151868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085398.2 → XP_038941326.2  COP9 signalosome complex subunit 3 isoform X1

  2. XM_039085399.2 → XP_038941327.1  COP9 signalosome complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y8F4
    Conserved Domains (1) summary
    pfam01399
    Location:239 → 342
    PCI; PCI domain

  3. XM_063268611.1 → XP_063124681.1  COP9 signalosome complex subunit 3 isoform X1

  4. XM_017597079.3 → XP_017452568.1  COP9 signalosome complex subunit 3 isoform X3

    Conserved Domains (1) summary
    pfam01399
    Location:129 → 232
    PCI; PCI domain

  5. XM_063268612.1 → XP_063124682.1  COP9 signalosome complex subunit 3 isoform X2

RNA

  1. XR_005489723.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FW9.1 GenPept UniProtKB/Swiss-Prot:Q68FW9

Gene LinkOut

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