Il4 interleukin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287287, updated on 10-Mar-2024

Summary

Official Symbol: Il4provided by RGD
Official Full Name: interleukin 4provided by RGD
Primary source: RGD:2898
See related: Ensembl:ENSRNOG00000007624 AllianceGenome:RGD:2898
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il4e12
Summary: Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (38272003..38277549, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (37771203..37776750, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (38963979..38969531, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF.
Title: Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF.
Pro-Fibrotic Role of Interleukin-4 in Influencing Idiopathic Epiretinal Membrane in Cataract Patients: Analysis From Clinical-Experimental Approaches.
Title: Pro-Fibrotic Role of Interleukin-4 in Influencing Idiopathic Epiretinal Membrane in Cataract Patients: Analysis From Clinical-Experimental Approaches.
Age and Sex Characteristics of the Blood Cytokine Profile in Rats Subjected to Prenatal Stress.
Title: Age and Sex Characteristics of the Blood Cytokine Profile in Rats Subjected to Prenatal Stress.
Moxibustion regulates the polarization of macrophages through the IL-4/STAT6 pathway in rheumatoid arthritis.
Title: Moxibustion regulates the polarization of macrophages through the IL-4/STAT6 pathway in rheumatoid arthritis.
IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation.
Title: IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation.
Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells.
Title: Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells.
Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia.
Title: Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia.
Shashen-Maidong decoction can improve the immune function of RP rats by increasing IFN-gamma concentration and decreasing IL-4 concentration, possibly by increasing the relative ratio of IFN-gamma/IL-4 to regulate the immune imbalance of Th1/Th2.
Title: Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats.
this study shows that IL-4 affects lipid metabolism and the expression of pro-inflammatory factors in mature rat adipocytes
Title: Interleukin 4 affects lipid metabolism and the expression of pro-inflammatory factors in mature rat adipocytes.
Bacterial overgrowth associated with bacterial translocation is linked to intestinal over-expression of IFN-gamma, IL-4, IL-17 and mucin-2 in cholestasis.
Title: Bacterial Translocation Is Linked to Increased Intestinal IFN-γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats.

Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Markers

D10MGH9 (e-PCR)
- UniSTS:120624

D10Wox9 (e-PCR)
- UniSTS:119237

UniSTS:143568 (e-PCR)
- UniSTS:143568

Il4 (e-PCR), detects polymorphism
- UniSTS:143568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-4 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell costimulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of MHC class II biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 1 cell lineage commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in interleukin-4-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of isotype switching to IgE isotypes	ISO Inferred from Sequence Orthology more info
acts_upstream_of isotype switching to IgG isotypes	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chronic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of white fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuroinflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of eosinophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of isotype switching to IgE isotypes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of proton transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-4

Names: B-cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IL-4; lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.