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PLCB1 phospholipase C beta 1 [ Bos taurus (cattle) ]

Gene ID: 287026, updated on 3-Apr-2024

Summary

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Official Symbol
PLCB1provided by VGNC
Official Full Name
phospholipase C beta 1provided by VGNC
Primary source
VGNC:VGNC:32980
See related
BGD:BT29800; Ensembl:ENSBTAG00000008338
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (932890..1794155)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346868 Neighboring gene uncharacterized LOC112449369 Neighboring gene microRNA mir-2285m-1 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC112449370 Neighboring gene phospholipase C beta 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities. Katan M, et al. Cell, 1988 Jul 15. PMID 2455601
  2. Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPα, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo. Kim S, et al. Genes Genomics, 2021 Aug. PMID 34129193
  3. Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits. Paterson A, et al. Cell Signal, 1995 Sep. PMID 8519600
  4. Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. Nishibe S, et al. J Biol Chem, 1989 Jun 25. PMID 2732223
  5. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. Tang Y, et al. J Biol Chem, 2000 Dec 1. PMID 10980202

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPalpha, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo.
    Title: Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPα, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Names
PLC-154
PLC-I
PLC-beta-1
phosphoinositide phospholipase C
phosphoinositide phospholipase C-beta-1
phospholipase C, beta 1 (phosphoinositide-specific)
NP_777242.1
XP_059748385.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174817.1 → NP_777242.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

    See identical proteins and their annotated locations for NP_777242.1

    Status: PROVISIONAL

    Source sequence(s)
    J03137
    UniProtKB/Swiss-Prot
    P10894
    UniProtKB/TrEMBL
    A0A3Q1LRN9
    Related
    ENSBTAP00000058710.2, ENSBTAT00000078977.2
    Conserved Domains (7) summary
    cd00275
    Location:677 → 796
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:316 → 643
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:216 → 784
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:22 → 148
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:903 → 939
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1003 → 1172
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:224 → 314
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    932890..1794155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059892402.1 → XP_059748385.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

    Related
    ENSBTAP00000046644.4, ENSBTAT00000049812.5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10894.1 GenPept UniProtKB/Swiss-Prot:P10894

Gene LinkOut

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Molecular Biology Databases
Research Materials
Miscellaneous