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Abi2 abl-interactor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286928, updated on 13-Apr-2024

Summary

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Official Symbol
Abi2provided by RGD
Official Full Name
abl-interactor 2provided by RGD
Primary source
RGD:628771
See related
Ensembl:ENSRNOG00000017707 AllianceGenome:RGD:628771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; lens fiber cell morphogenesis; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within several processes, including dendrite development; learning or memory; and peptidyl-tyrosine phosphorylation. Predicted to be located in several cellular components, including dendrite; filopodium tip; and nucleoplasm. Predicted to be part of SCAR complex. Predicted to be active in several cellular components, including adherens junction; glutamatergic synapse; and postsynaptic actin cytoskeleton. Predicted to colocalize with actin filament. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 483.5), Heart (RPKM 145.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69321072..69490630)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61827186..61905703)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67234612..67284504)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2, pseudogene 1 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene uncharacterized LOC102547711 Neighboring gene small nucleolar RNA SNORA51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a complementary DNA for a thyroid hormone-responsive protein in mature rat cerebral tissue. Shah GN, et al. Biochem J, 1997 Oct 15. PMID 9359437, Free PMC Article
  2. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Dai Z, et al. Genes Dev, 1995 Nov 1. PMID 7590236
  3. Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2. Kano S, et al. Cancer Res, 2008 Jul 15. PMID 18632609
  4. ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Grove M, et al. Mol Cell Biol, 2004 Dec. PMID 15572692, Free PMC Article
  5. The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. Stradal T, et al. Curr Biol, 2001 Jun 5. PMID 11516653

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendrite development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within learning or memory ISO
Inferred from Sequence Orthology
more info
  
involved_in lens fiber cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in zonula adherens assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
abl interactor 2
Names
rCG22366-like
thyroid hormone responsive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393698.1 → NP_001380627.1  abl interactor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6IPC7, F1LYA6
    Related
    ENSRNOP00000080678.1, ENSRNOT00000117396.1
    Conserved Domains (2) summary
    cd11972
    Location:413 → 473
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  2. NM_173143.2 → NP_775166.2  abl interactor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    F1LYA6
    Related
    ENSRNOP00000082875.1, ENSRNOT00000111854.1
    Conserved Domains (1) summary
    cd11972
    Location:384 → 444
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    69321072..69490630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266759.1 → XP_063122829.1  abl interactor 2 isoform X11

    UniProtKB/TrEMBL
    A6IPC6

  2. XM_063266783.1 → XP_063122853.1  abl interactor 2 isoform X33

    UniProtKB/TrEMBL
    A6IPC8

  3. XM_063266777.1 → XP_063122847.1  abl interactor 2 isoform X27

  4. XM_063266772.1 → XP_063122842.1  abl interactor 2 isoform X23

  5. XM_063266748.1 → XP_063122818.1  abl interactor 2 isoform X1

  6. XM_063266793.1 → XP_063122863.1  abl interactor 2 isoform X42

  7. XM_063266799.1 → XP_063122869.1  abl interactor 2 isoform X48

  8. XM_063266749.1 → XP_063122819.1  abl interactor 2 isoform X2

  9. XM_063266795.1 → XP_063122865.1  abl interactor 2 isoform X44

  10. XM_063266755.1 → XP_063122825.1  abl interactor 2 isoform X7

  11. XM_063266785.1 → XP_063122855.1  abl interactor 2 isoform X35

  12. XM_063266756.1 → XP_063122826.1  abl interactor 2 isoform X8

  13. XM_063266768.1 → XP_063122838.1  abl interactor 2 isoform X19

  14. XM_063266765.1 → XP_063122835.1  abl interactor 2 isoform X16

  15. XM_063266750.1 → XP_063122820.1  abl interactor 2 isoform X3

  16. XM_063266763.1 → XP_063122833.1  abl interactor 2 isoform X15

  17. XM_063266771.1 → XP_063122841.1  abl interactor 2 isoform X22

  18. XM_063266767.1 → XP_063122837.1  abl interactor 2 isoform X18

  19. XM_063266784.1 → XP_063122854.1  abl interactor 2 isoform X34

  20. XM_063266754.1 → XP_063122824.1  abl interactor 2 isoform X6

  21. XM_063266762.1 → XP_063122832.1  abl interactor 2 isoform X14

  22. XM_063266766.1 → XP_063122836.1  abl interactor 2 isoform X17

  23. XM_063266798.1 → XP_063122868.1  abl interactor 2 isoform X47

  24. XM_063266774.1 → XP_063122844.1  abl interactor 2 isoform X25

  25. XM_063266758.1 → XP_063122828.1  abl interactor 2 isoform X10

  26. XM_063266770.1 → XP_063122840.1  abl interactor 2 isoform X21

  27. XM_063266773.1 → XP_063122843.1  abl interactor 2 isoform X24

  28. XM_063266787.1 → XP_063122857.1  abl interactor 2 isoform X36

  29. XM_063266778.1 → XP_063122848.1  abl interactor 2 isoform X28

  30. XM_063266751.1 → XP_063122821.1  abl interactor 2 isoform X4

  31. XM_063266761.1 → XP_063122831.1  abl interactor 2 isoform X13

  32. XM_063266752.1 → XP_063122822.1  abl interactor 2 isoform X5

  33. XM_063266797.1 → XP_063122867.1  abl interactor 2 isoform X46

  34. XM_063266757.1 → XP_063122827.1  abl interactor 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZLD3

  35. XM_063266769.1 → XP_063122839.1  abl interactor 2 isoform X20

    UniProtKB/TrEMBL
    A0A8I5ZQU4

  36. XM_063266776.1 → XP_063122846.1  abl interactor 2 isoform X26

  37. XM_063266760.1 → XP_063122830.1  abl interactor 2 isoform X12

  38. XM_063266779.1 → XP_063122849.1  abl interactor 2 isoform X29

    UniProtKB/TrEMBL
    A0A8I5ZKW2

  39. XM_063266788.1 → XP_063122858.1  abl interactor 2 isoform X37

  40. XM_063266791.1 → XP_063122861.1  abl interactor 2 isoform X40

  41. XM_063266780.1 → XP_063122850.1  abl interactor 2 isoform X30

  42. XM_063266792.1 → XP_063122862.1  abl interactor 2 isoform X41

  43. XM_063266790.1 → XP_063122860.1  abl interactor 2 isoform X39

  44. XM_063266782.1 → XP_063122852.1  abl interactor 2 isoform X32

  45. XM_063266794.1 → XP_063122864.1  abl interactor 2 isoform X43

  46. XM_063266789.1 → XP_063122859.1  abl interactor 2 isoform X38

  47. XM_063266781.1 → XP_063122851.1  abl interactor 2 isoform X31

    UniProtKB/TrEMBL
    A0A8I5ZVR4

  48. XM_063266796.1 → XP_063122866.1  abl interactor 2 isoform X45

Nucleotide Protein Strain
Heading Accession and Version

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