mc4r melanocortin 4 receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mc4rprovided by ZNC
Official Full Name: melanocortin 4 receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021223-2
See related: Ensembl:ENSDARG00000015515 AllianceGenome:ZFIN:ZDB-GENE-021223-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zMC4; MC4-R; si:dkey-151m6.62
Summary: Enables melanocortin receptor activity. Involved in energy homeostasis and energy reserve metabolic process. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of feeding behavior; and regulation of growth. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain and myotome. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (27932781..27933761)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (28277145..28278125)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRAP2b decreases the constitutive activity of the MC4R during fasting periods, driving the animal toward a positive energy balance.
Title: Melanocortin 4 receptor becomes an ACTH receptor by coexpression of melanocortin receptor accessory protein 2.
MRAP2 proteins allow for developmental control of MC4R activity, with MRAP2a blocking its function and stimulating growth during larval development, whereas MRAP2b enhances responsiveness to alpha-MSH once the zebrafish begins feeding, thus increasing the capacity for regulated feeding and growth.
Title: Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables melanocortin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables melanocortin receptor activity	IEA Inferred from Electronic Annotation more info
enables melanocyte-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in energy homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in energy reserve metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melanocortin receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173278.1 → NP_775385.1 melanocortin receptor 4

See identical proteins and their annotated locations for NP_775385.1

Status: PROVISIONAL

Source sequence(s)

AY078989

UniProtKB/Swiss-Prot

B0V1P1, Q8JGW3

Related

ENSDARP00000027547.2, ENSDART00000019555.5

Conserved Domains (2) summary

pfam00001
Location:58 → 300

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 314

7tm_4; Olfactory receptor