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LIN9 lin-9 DREAM MuvB core complex component [ Homo sapiens (human) ]

Gene ID: 286826, updated on 11-Apr-2024

Summary

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Official Symbol
LIN9provided by HGNC
Official Full Name
lin-9 DREAM MuvB core complex componentprovided by HGNC
Primary source
HGNC:HGNC:30830
See related
Ensembl:ENSG00000183814 MIM:609375; AllianceGenome:HGNC:30830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGS; BARA; TGS1; TGS2; Lin-9; BARPsv
Summary
This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Broad expression in testis (RPKM 3.7), heart (RPKM 2.8) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
1q42.12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (226231149..226309767, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (225419172..225497821, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226418850..226497468, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2647 Neighboring gene Sharpr-MPRA regulatory region 4175 Neighboring gene Mix paired-like homeobox Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226495998-226496764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1882 Neighboring gene small nucleolar RNA U13 Neighboring gene Y-box binding protein 1 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors. Sahni JM, et al. Cancer Res, 2017 Oct 1. PMID 28807940, Free PMC Article
  2. LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. Eckerdt F, et al. PLoS One, 2014. PMID 24475316, Free PMC Article
  3. Mip/LIN-9 can inhibit cell proliferation independent of the pocket proteins. Pilkinton M, et al. Blood Cells Mol Dis, 2007 Nov-Dec. PMID 17618148, Free PMC Article
  4. LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance. Roberts MS, et al. Cancer Res, 2020 Apr 15. PMID 32054769, Free PMC Article
  5. LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells. Esterlechner J, et al. PLoS One, 2013. PMID 23667535, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.
    Title: LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.
  2. High LIN9 expression is associated with Triple-negative breast cancers.
    Title: Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.
  3. The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells.
    Title: Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.
  4. LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.
    Title: LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.
  5. Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters.
    Title: A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c).
  6. Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms.
    Title: A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.
  7. inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen
    Title: Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.
  10. The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction.
    Title: Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reproductive process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein lin-9 homolog
Names
TUDOR gene similar protein
beta subunit-associated regulator of apoptosis
lin-9 homolog
pRB-associated protein
rb related pathway actor
type I interferon receptor beta chain-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270409.1 → NP_001257338.1  protein lin-9 homolog isoform 2

    See identical proteins and their annotated locations for NP_001257338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AF190323, AL359742, BC045625, BX284931
    UniProtKB/TrEMBL
    H7C4T7
    Related
    ENSP00000418121.1, ENST00000460719.5
    Conserved Domains (1) summary
    pfam06584
    Location:108 → 212
    DIRP; DIRP

  2. NM_001270410.2 → NP_001257339.1  protein lin-9 homolog isoform 3

    See identical proteins and their annotated locations for NP_001257339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF190323, AL359742, BC065302, BX284931
    Consensus CDS
    CCDS91164.1
    UniProtKB/TrEMBL
    H0Y322, Q6P142
    Related
    ENSP00000355773.2, ENST00000366808.6
    Conserved Domains (1) summary
    pfam06584
    Location:75 → 179
    DIRP; DIRP

  3. NM_001366237.1 → NP_001353166.1  protein lin-9 homolog isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    UniProtKB/TrEMBL
    H7C4T7
    Conserved Domains (1) summary
    pfam06584
    Location:143 → 247
    DIRP

  4. NM_001366238.1 → NP_001353167.1  protein lin-9 homolog isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    UniProtKB/TrEMBL
    H7C4T7
    Conserved Domains (1) summary
    pfam06584
    Location:142 → 246
    DIRP

  5. NM_001366239.1 → NP_001353168.1  protein lin-9 homolog isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    UniProtKB/TrEMBL
    H7C4T7
    Conserved Domains (1) summary
    pfam06584
    Location:143 → 247
    DIRP; DIRP

  6. NM_001366240.1 → NP_001353169.1  protein lin-9 homolog isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    UniProtKB/TrEMBL
    H7C4T7
    Conserved Domains (1) summary
    pfam06584
    Location:34 → 138
    DIRP

  7. NM_001366241.1 → NP_001353170.1  protein lin-9 homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Consensus CDS
    CCDS91164.1
    UniProtKB/TrEMBL
    H0Y322, Q6P142
    Conserved Domains (1) summary
    pfam06584
    Location:75 → 179
    DIRP; DIRP

  8. NM_001366245.2 → NP_001353174.1  protein lin-9 homolog isoform 8

    Status: REVIEWED

    Source sequence(s)
    AF190324, BX284931
    Consensus CDS
    CCDS91165.1
    UniProtKB/Swiss-Prot
    Q5TKA1, Q5U5L8, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1
    UniProtKB/TrEMBL
    Q6P142
    Related
    ENSP00000505590.1, ENST00000681046.1
    Conserved Domains (1) summary
    pfam06584
    Location:127 → 231
    DIRP; DIRP

  9. NM_173083.3 → NP_775106.2  protein lin-9 homolog isoform 1

    See identical proteins and their annotated locations for NP_775106.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AF190323, AL359742, BC045625
    Consensus CDS
    CCDS1553.1
    UniProtKB/TrEMBL
    H7C4T7
    Related
    ENSP00000329102.5, ENST00000328205.9
    Conserved Domains (1) summary
    pfam06584
    Location:143 → 247
    DIRP; DIRP

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    226231149..226309767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001084.2 → XP_016856573.2  protein lin-9 homolog isoform X3

  2. XM_047418546.1 → XP_047274502.1  protein lin-9 homolog isoform X2

  3. XM_024446565.2 → XP_024302333.2  protein lin-9 homolog isoform X1

  4. XM_047418553.1 → XP_047274509.1  protein lin-9 homolog isoform X6

  5. XM_006711767.5 → XP_006711830.1  protein lin-9 homolog isoform X5

    See identical proteins and their annotated locations for XP_006711830.1

    UniProtKB/TrEMBL
    H0Y322, Q6P142
    Conserved Domains (1) summary
    pfam06584
    Location:75 → 179
    DIRP; DIRP

  6. XM_047418556.1 → XP_047274512.1  protein lin-9 homolog isoform X7

  7. XM_011544173.3 → XP_011542475.2  protein lin-9 homolog isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    225419172..225497821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336155.1 → XP_054192130.1  protein lin-9 homolog isoform X3

  2. XM_054336154.1 → XP_054192129.1  protein lin-9 homolog isoform X2

  3. XM_054336153.1 → XP_054192128.1  protein lin-9 homolog isoform X1

  4. XM_054336158.1 → XP_054192133.1  protein lin-9 homolog isoform X6

  5. XM_054336157.1 → XP_054192132.1  protein lin-9 homolog isoform X5

    UniProtKB/TrEMBL
    H0Y322

  6. XM_054336156.1 → XP_054192131.1  protein lin-9 homolog isoform X4

  7. XM_054336159.1 → XP_054192134.1  protein lin-9 homolog isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TKA1.1 GenPept UniProtKB/Swiss-Prot:Q5TKA1

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