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FFAR2 free fatty acid receptor 2 [ Homo sapiens (human) ]

Gene ID: 2867, updated on 11-Apr-2024

Summary

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Official Symbol
FFAR2provided by HGNC
Official Full Name
free fatty acid receptor 2provided by HGNC
Primary source
HGNC:HGNC:4501
See related
Ensembl:ENSG00000126262 MIM:603823; AllianceGenome:HGNC:4501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFA2R; GPR43
Summary
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
Expression
Biased expression in appendix (RPKM 7.9), bone marrow (RPKM 5.6) and 11 other tissues See more
Orthologs
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Genomic context

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See FFAR2 in Genome Data Viewer
Location:
19q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35448257..35451767)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37992993..37996503)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35939159..35942669)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene RNA, 7SL, cytoplasmic 491, pseudogene Neighboring gene uncharacterized LOC101927522 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:35923796-35924995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35927445-35928408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35928409-35929370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14481 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35959455-35960028 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35961751-35962324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10527 Neighboring gene uncharacterized LOC124904703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35985748-35986694 Neighboring gene keratinocyte differentiation associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling. Wang G, et al. Cell Death Dis, 2023 Apr 25. PMID 37185889, Free PMC Article
  2. Constitutively active GPR43 is crucial for proper leukocyte differentiation. Miyasato S, et al. FASEB J, 2023 Jan. PMID 36468834
  3. Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils. Frei R, et al. J Leukoc Biol, 2021 Apr. PMID 32803826, Free PMC Article
  4. Oncoprotective Effects of Short-Chain Fatty Acids on Uterine Cervical Neoplasia. Matsuya-Ogawa M, et al. Nutr Cancer, 2019. PMID 30836015
  5. Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling. Schofield ZV, et al. Sci Rep, 2018 Dec 13. PMID 30546040, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner.
    Title: Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner.
  2. Dietary Fiber Improves Skin Wound Healing and Scar Formation through the Metabolite-Sensing Receptor GPR43.
    Title: Dietary Fiber Improves Skin Wound Healing and Scar Formation through the Metabolite-Sensing Receptor GPR43.
  3. Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.
    Title: Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.
  4. Upregulated expression of FFAR2 and SOC3 genes is associated with gout.
    Title: Upregulated expression of FFAR2 and SOC3 genes is associated with gout.
  5. Constitutively active GPR43 is crucial for proper leukocyte differentiation.
    Title: Constitutively active GPR43 is crucial for proper leukocyte differentiation.
  6. GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics.
    Title: GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics.
  7. GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKalpha activity.
    Title: GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity.
  8. Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils.
    Title: Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils.
  9. Microbiota-derived short chain fatty acid promotion of Amphiregulin expression by dendritic cells is regulated by GPR43 and Blimp-1.
    Title: Microbiota-derived short chain fatty acid promotion of Amphiregulin expression by dendritic cells is regulated by GPR43 and Blimp-1.
  10. FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells.
    Title: FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface pattern recognition receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to fatty acid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in leukocyte chemotaxis involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ligand-gated ion channel signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of chemokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of acute inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of peptide hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
free fatty acid receptor 2
Names
G-protein coupled receptor 43
fatty acid receptor 2
free fatty acid activated receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370087.1 → NP_001357016.1  free fatty acid receptor 2

    Status: REVIEWED

    Source sequence(s)
    AC002511
    Consensus CDS
    CCDS12461.1
    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4
    Related
    ENSP00000473159.1, ENST00000599180.3
    Conserved Domains (1) summary
    cd15170
    Location:9 → 286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_005306.3 → NP_005297.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_005297.1

    Status: REVIEWED

    Source sequence(s)
    AC002511
    Consensus CDS
    CCDS12461.1
    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4
    Conserved Domains (1) summary
    cd15170
    Location:9 → 286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35448257..35451767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438699.1 → XP_047294655.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4

  2. XM_047438700.1 → XP_047294656.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4
    Related
    ENSP00000246549.2, ENST00000246549.2

  3. XM_017026711.2 → XP_016882200.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4
    Conserved Domains (1) summary
    cd15170
    Location:9 → 286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37992993..37996503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320734.1 → XP_054176709.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4

  2. XM_054320736.1 → XP_054176711.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4

  3. XM_054320735.1 → XP_054176710.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B0M0J9, O15552, Q4VAZ3, Q4VAZ5, Q4VBL5
    UniProtKB/TrEMBL
    C6KYL4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15552.1 GenPept UniProtKB/Swiss-Prot:O15552

Gene LinkOut

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