GPR39 G protein-coupled receptor 39 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR39provided by HGNC
Official Full Name: G protein-coupled receptor 39provided by HGNC
Primary source: HGNC:HGNC:4496
See related: Ensembl:ENSG00000183840 MIM:602886; AllianceGenome:HGNC:4496
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZnR
Summary: This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
Expression: Broad expression in brain (RPKM 4.2), colon (RPKM 3.1) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q21.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (132416805..132646582)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (132855128..133084942)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (133174378..133404155)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles.
Title: Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles.
GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain.
Title: GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain.
Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39.
Title: Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39.
G protein-coupled receptor 39 alleviates mitochondrial dysfunction and hepatocyte lipid accumulation via SIRT1/Nrf2 signaling.
Title: G protein-coupled receptor 39 alleviates mitochondrial dysfunction and hepatocyte lipid accumulation via SIRT1/Nrf2 signaling.
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis.
Title: Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis.
The expression and clinical significance of GPR39 in colon cancer.
Title: The expression and clinical significance of GPR39 in colon cancer.
Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.
Title: Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.
Interaction between Zinc, GPR39, BDNF and Neuropeptides in Depression.
Title: Interaction between Zinc, GPR39, BDNF and Neuropeptides in Depression.
GPR39 promotes cardiac hypertrophy by regulating the AMPK-mTOR pathway and protein synthesis.
Title: GPR39 promotes cardiac hypertrophy by regulating the AMPK-mTOR pathway and protein synthesis.
ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP.
Title: ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Two-marker association tests yield new disease associations for coronary artery disease and hypertension. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S112 (e-PCR), detects polymorphism
- UniSTS:45088

RH44409 (e-PCR)
- UniSTS:80979

SHGC-79913 (e-PCR)
- UniSTS:101482

RH80444 (e-PCR)
- UniSTS:92525

D2S112 (e-PCR), detects polymorphism
- UniSTS:7054

MGC29643__7700 (e-PCR)
- UniSTS:466325

D2S2219 (e-PCR)
- UniSTS:47260

RH65413 (e-PCR)
- UniSTS:64424

REN4084 (e-PCR)
- UniSTS:328884

D2S1415 (e-PCR)
- UniSTS:30431

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: G-protein coupled receptor 39

Names: zinc sensing receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.