Mc2r melanocortin 2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mc2rprovided by RGD
Official Full Name: melanocortin 2 receptorprovided by RGD
Primary source: RGD:628649
See related: Ensembl:ENSRNOG00000016681 AllianceGenome:RGD:628649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity. Involved in placenta development. Located in cytoplasm and plasma membrane. Biomarker of toxic shock syndrome. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 393.7) and Muscle (RPKM 25.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (64279878..64291775, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (62001980..62015567, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (64166959..64178729, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data demonstrated that the abnormal proliferation of vascular smooth muscle cells induced by conditions of high cyclic strain is in part attributed to ACTH and its receptor MC2R.
Title: Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway.
Data suggest that increases in adrenal blood flow induced by Ang II (angiotensin II)/Agtr2 signaling are mediated by release of nitric oxide and EETs (epoxyeicosatrienoic acids); increases in adrenal blood flow with ACTH (adrenocorticotropic hormone)/Mc2r receptor signaling are mediated by EETs only. (Agtr2 = angiotensin II receptor; Mc2r = ACTH receptor)
Title: Effect of Angiotensin II and ACTH on Adrenal Blood Flow in the Male Rat Adrenal Gland In Vivo.
Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors.
Title: Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors.
The results showed that the haplotype TCCT in MC2R promoter significantly led to increased MC2R expression and strong responses to adrenocorticotropin hormone.
Title: ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH.
Upregulation of adrenal MC2 and AT(2) receptors seems to be involved in the stimulated facilitation of adrenal corticosterone release for effectuating the stimulated stress responses.
Title: Stress sensitivity is increased in transgenic rats with low brain angiotensinogen.
CRF is released in the locus coerulus during swim stress to activate this system and initiate cellular trafficking of the receptor that determines subsequent sensitivity of locus coerulus neurons to CRF.
Title: Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons.

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General gene information

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Markers

Mc2r (e-PCR), detects polymorphism
- UniSTS:464680

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in placenta development	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adrenocorticotropic hormone receptor

Names: melanocortin 2 receptor (adrenocorticotropic hormone)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100491.1 → NP_001093961.1 adrenocorticotropic hormone receptor

See identical proteins and their annotated locations for NP_001093961.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A6IXY0, G3V848, Q8CIX6

Related

ENSRNOP00000022347.3, ENSRNOT00000022347.6

Conserved Domains (1) summary

cd15350
Location:25 → 287

7tmA_MC2R_ACTH_R; melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

64279878..64291775 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277136.1 → XP_063133206.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277135.1 → XP_063133205.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277140.1 → XP_063133210.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277137.1 → XP_063133207.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277138.1 → XP_063133208.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277139.1 → XP_063133209.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_008772094.4 → XP_008770316.1 adrenocorticotropic hormone receptor isoform X1

See identical proteins and their annotated locations for XP_008770316.1

UniProtKB/TrEMBL

A6IXY0, G3V848, Q8CIX6

Conserved Domains (1) summary

cd15350
Location:25 → 287

7tmA_MC2R_ACTH_R; melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_008772095.4 → XP_008770317.1 adrenocorticotropic hormone receptor isoform X1

See identical proteins and their annotated locations for XP_008770317.1

UniProtKB/TrEMBL

A6IXY0, G3V848, Q8CIX6

Conserved Domains (1) summary

cd15350
Location:25 → 287

7tmA_MC2R_ACTH_R; melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063277141.1 → XP_063133211.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277144.1 → XP_063133214.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277143.1 → XP_063133213.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277142.1 → XP_063133212.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848
XM_063277145.1 → XP_063133215.1 adrenocorticotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A6IXY0, G3V848