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Wnt5b Wnt family member 5B [ Rattus norvegicus (Norway rat) ]

Gene ID: 282582, updated on 3-Apr-2024

Summary

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Official Symbol
Wnt5bprovided by RGD
Official Full Name
Wnt family member 5Bprovided by RGD
Primary source
RGD:628850
See related
Ensembl:ENSRNOG00000008168 AllianceGenome:RGD:628850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in wound healing. Predicted to be located in cell surface and extracellular matrix. Predicted to be active in extracellular space. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 24.3), Lung (RPKM 21.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (154281852..154406081, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (152609566..152733790, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (151500962..151516894, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene adiponectin receptor 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134486631 Neighboring gene F-box and leucine-rich repeat protein 14 Neighboring gene uncharacterized LOC134486632 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of Wnt and MMP in epithelial cells during corneal wound healing. Lyu J, et al. Cornea, 2006 Dec. PMID 17001188
  2. Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor. Mangioni S, et al. J Clin Endocrinol Metab, 2005 Sep. PMID 15972578
  3. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Morioka K, et al. Cancer Sci, 2009 Jul. PMID 19486338
  4. Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Kanazawa A, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796911
  5. Expression of members of Wnt and Frizzled gene families in the postnatal rat cochlea. Daudet N, et al. Brain Res Mol Brain Res, 2002 Sep 30. PMID 12399112

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein Wnt-5b
Names
wingless-related MMTV integration site 5B
wingless-type MMTV integration site family, member 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100489.1 → NP_001093959.1  protein Wnt-5b

    See identical proteins and their annotated locations for NP_001093959.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    B1WBR9, F7FL18
    Conserved Domains (1) summary
    cl38924
    Location:61 → 372
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    154281852..154406081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107158.2 → XP_038963086.1  protein Wnt-5b isoform X1

    UniProtKB/TrEMBL
    B1WBR9, F7FL18
    Conserved Domains (1) summary
    cl38924
    Location:61 → 372
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

  2. XM_039107157.2 → XP_038963085.1  protein Wnt-5b isoform X1

    UniProtKB/TrEMBL
    B1WBR9, F7FL18
    Related
    ENSRNOP00000011044.4
    Conserved Domains (1) summary
    cl38924
    Location:61 → 372
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

  3. XM_063285651.1 → XP_063141721.1  protein Wnt-5b isoform X1

    UniProtKB/TrEMBL
    B1WBR9, F7FL18
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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