U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fzd6 frizzled class receptor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 282581, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Fzd6provided by RGD
Official Full Name
frizzled class receptor 6provided by RGD
Primary source
RGD:628816
See related
Ensembl:ENSRNOG00000004660 AllianceGenome:RGD:628816
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Wnt-activated receptor activity; Wnt-protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Predicted to be located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 79.3), Kidney (RPKM 74.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (71939916..71971685)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (70055012..70086781)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (77898329..77931034)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene BAALC binder of MAP3K1 and KLF4 Neighboring gene uncharacterized LOC134479898 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479899

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Order from disorder: Self-organization in mammalian hair patterning. Wang Y, et al. Proc Natl Acad Sci U S A, 2006 Dec 26. PMID 17172440, Free PMC Article
  2. Frizzled6 controls hair patterning in mice. Guo N, et al. Proc Natl Acad Sci U S A, 2004 Jun 22. PMID 15169958, Free PMC Article
  3. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. Golan T, et al. J Biol Chem, 2004 Apr 9. PMID 14747478
  4. Expression of members of Wnt and Frizzled gene families in the postnatal rat cochlea. Daudet N, et al. Brain Res Mol Brain Res, 2002 Sep 30. PMID 12399112
  5. Canonical Wnt signaling negatively regulates platelet function. Steele BM, et al. Proc Natl Acad Sci U S A, 2009 Nov 24. PMID 19901330, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell proliferation in midbrain ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic nail plate morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of body hair planar orientation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of planar polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within midbrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
frizzled-6
Names
frizzled family receptor 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130536.1 → NP_001124008.1  frizzled-6 precursor

    See identical proteins and their annotated locations for NP_001124008.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A6HR66, G3V6L1
    Related
    ENSRNOP00000006195.5, ENSRNOT00000006195.6
    Conserved Domains (2) summary
    cd07450
    Location:20 → 146
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    cd15032
    Location:188 → 508
    7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    71939916..71971685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594684.3 → XP_017450173.1  frizzled-6 isoform X1

    UniProtKB/TrEMBL
    A6HR66, G3V6L1
    Conserved Domains (2) summary
    cd07450
    Location:20 → 146
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    cd15032
    Location:188 → 508
    7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

  2. XM_039078519.1 → XP_038934447.1  frizzled-6 isoform X1

    UniProtKB/TrEMBL
    A6HR66, G3V6L1
    Conserved Domains (2) summary
    cd07450
    Location:20 → 146
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    cd15032
    Location:188 → 508
    7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

  3. XM_039078520.1 → XP_038934448.1  frizzled-6 isoform X1

    UniProtKB/TrEMBL
    A6HR66, G3V6L1
    Conserved Domains (2) summary
    cd07450
    Location:20 → 146
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    cd15032
    Location:188 → 508
    7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

  4. XM_063263073.1 → XP_063119143.1  frizzled-6 isoform X1

    UniProtKB/TrEMBL
    A6HR66, G3V6L1

  5. XM_017594686.3 → XP_017450175.1  frizzled-6 isoform X1

    UniProtKB/TrEMBL
    A6HR66, G3V6L1
    Conserved Domains (2) summary
    cd07450
    Location:20 → 146
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    cd15032
    Location:188 → 508
    7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

  6. XM_063263074.1 → XP_063119144.1  frizzled-6 isoform X2

  7. XM_063263075.1 → XP_063119145.1  frizzled-6 isoform X3

RNA

  1. XR_005486551.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous