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GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 [ Bos taurus (cattle) ]

Gene ID: 282433, updated on 5-Mar-2024

Summary

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Official Symbol
GUCY1B1provided by VGNC
Official Full Name
guanylate cyclase 1 soluble subunit beta 1provided by VGNC
Primary source
VGNC:VGNC:29721
See related
BGD:BT19881; Ensembl:ENSBTAG00000003840
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GUCY1B3
Orthologs
human mouse all
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Genomic context

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See GUCY1B1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (43514976..43577750, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene tryptophan 2,3-dioxygenase Neighboring gene acid sensing ion channel subunit family member 5 Neighboring gene guanylate cyclase 1 soluble subunit alpha 1 Neighboring gene uncharacterized LOC101904168

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand. Zhao Y, et al. Biochemistry, 1998 Mar 31. PMID 9521770
  2. Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase. Wedel B, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 7908439, Free PMC Article
  3. The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase. Koesling D, et al. FEBS Lett, 1988 Oct 24. PMID 2903071
  4. Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation. Sarkar A, et al. J Biol Chem, 2015 Aug 28. PMID 26134567, Free PMC Article
  5. Dimerization of nitric oxide-sensitive guanylyl cyclase requires the alpha 1 N terminus. Wagner C, et al. J Biol Chem, 2005 May 6. PMID 15749699

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxygen levels IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of guanylate cyclase complex, soluble IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanylate cyclase soluble subunit beta-1
Names
GCS-beta-1
GCS-beta-3
NO-sensitive GC beta 1 subunit
guanylate cyclase 1, soluble, beta 3
guanylate cyclase soluble subunit beta-3
nitric oxide-sensitive guanylyl cyclase beta 1 subunit
soluble guanylate cyclase small subunit
NP_777066.1
XP_010812118.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174641.1 → NP_777066.1  guanylate cyclase soluble subunit beta-1

    See identical proteins and their annotated locations for NP_777066.1

    Status: PROVISIONAL

    Source sequence(s)
    Y00770
    UniProtKB/Swiss-Prot
    A2VDM4, P16068
    Related
    ENSBTAP00000102396.1, ENSBTAT00000133044.1
    Conserved Domains (4) summary
    smart00044
    Location:385 → 584
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:412 → 605
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:2 → 166
    HNOB; Haem-NO-binding
    pfam07701
    Location:207 → 406
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43514976..43577750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010813816.4 → XP_010812118.1  guanylate cyclase soluble subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_010812118.1

    Conserved Domains (3) summary
    pfam00211
    Location:344 → 537
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:1 → 98
    HNOB; Haem-NO-binding
    pfam07701
    Location:139 → 338
    HNOBA; Heme NO binding associated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16068.1 GenPept UniProtKB/Swiss-Prot:P16068

Gene LinkOut

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