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STAT5B signal transducer and activator of transcription 5B [ Bos taurus (cattle) ]

Gene ID: 282376, updated on 11-Apr-2024

Summary

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Official Symbol
STAT5Bprovided by VGNC
Official Full Name
signal transducer and activator of transcription 5Bprovided by VGNC
Primary source
VGNC:VGNC:35373
See related
BGD:BT12344; Ensembl:ENSBTAG00000010125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (42319167..42384915, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene signal transducer and activator of transcription 5A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of growth hormone on the differentiation of bovine preadipocytes into adipocytes and the role of the signal transducer and activator of transcription 5b. Zhao L, et al. J Anim Sci, 2014 May. PMID 24668956
  2. A highly polymorphic GT-repeat in the bovine STAT5B encoding gene on BTA19. Meyer L, et al. Anim Genet, 1999 Feb. PMID 10050298
  3. Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle. Usman T, et al. Anim Genet, 2015 Aug. PMID 26154111
  4. Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains. Seyfert HM, et al. J Mol Evol, 2000 Jun. PMID 10835485
  5. Association of bovine CD4 and STAT5b single nucleotide polymorphisms with somatic cell scores and milk production traits in Chinese Holsteins. He Y, et al. J Dairy Res, 2011 May. PMID 21435309

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNPs in JAK2 and STAT5B are associated with mastitis susceptibility in Chinese Holstein cattle
    Title: Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle.
  2. This study suggests that growth hormone inhibits the differentiation of bovine preadipocytes to adipocytes through STAT5b-dependent inhibition of C/EBPalpha and PPARgamma expression.
    Title: Effect of growth hormone on the differentiation of bovine preadipocytes into adipocytes and the role of the signal transducer and activator of transcription 5b.
  3. These results suggested that the SNPs in CD4 and STAT5b may be potential genetic markers for SCS and milk/protein yields selecting and warrant further functional research.
    Title: Association of bovine CD4 and STAT5b single nucleotide polymorphisms with somatic cell scores and milk production traits in Chinese Holsteins.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC137362

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174617.4 → NP_777042.2  signal transducer and activator of transcription 5B

    See identical proteins and their annotated locations for NP_777042.2

    Status: PROVISIONAL

    Source sequence(s)
    BC112568
    UniProtKB/Swiss-Prot
    O77702, Q2KIP0, Q9TUM2, Q9TUM3
    UniProtKB/TrEMBL
    A0A140T878
    Related
    ENSBTAP00000012497.3, ENSBTAT00000012497.5
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42319167..42384915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005220673.5 → XP_005220730.1  signal transducer and activator of transcription 5B isoform X1

    See identical proteins and their annotated locations for XP_005220730.1

    UniProtKB/Swiss-Prot
    O77702, Q2KIP0, Q9TUM2, Q9TUM3
    UniProtKB/TrEMBL
    A0A140T878
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. XM_024979633.2 → XP_024835401.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/Swiss-Prot
    O77702, Q2KIP0, Q9TUM2, Q9TUM3
    UniProtKB/TrEMBL
    A0A140T878
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  3. XM_005220675.5 → XP_005220732.1  signal transducer and activator of transcription 5B isoform X4

    UniProtKB/Swiss-Prot
    O77702, Q2KIP0, Q9TUM2, Q9TUM3
    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:39 → 228
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:230 → 480
    STAT_bind; STAT protein, DNA binding domain
    cl03749
    Location:1 → 23
    STAT_int; STAT protein, protein interaction domain

  4. XM_059877733.1 → XP_059733716.1  signal transducer and activator of transcription 5B isoform X3

  5. XM_059877732.1 → XP_059733715.1  signal transducer and activator of transcription 5B isoform X2

    Related
    ENSBTAP00000091027.1, ENSBTAT00000107449.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TUM3.2 GenPept UniProtKB/Swiss-Prot:Q9TUM3

Gene LinkOut

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