U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRKCB protein kinase C beta [ Bos taurus (cattle) ]

Gene ID: 282325, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PRKCBprovided by VGNC
Official Full Name
protein kinase C betaprovided by VGNC
Primary source
VGNC:VGNC:33328
See related
BGD:BT10706; Ensembl:ENSBTAG00000020921
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PRKCB1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 25
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (21505317..21880937)

Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC107131818 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 3 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene RB binding protein 6, ubiquitin ligase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nishizuka Y. Nature, 1988 Aug 25. PMID 3045562
  2. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Coussens L, et al. Science, 1986 Aug 22. PMID 3755548
  3. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. Whalen SG, et al. J Biol Chem, 1996 May 17. PMID 8662663
  4. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Park K, et al. Mol Cell Biol, 2013 Aug. PMID 23775122, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study identified the serine phosphorylation (p-Ser) sites induced by PKC-Beta activation or AGT, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells.
    Title: Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein kinase C beta type
Names
PKC-B
PKC-beta
protein kinase C, beta 1 polypeptide
NP_777012.1
XP_005224747.1
XP_015315798.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174587.1 → NP_777012.1  protein kinase C beta type

    See identical proteins and their annotated locations for NP_777012.1

    Status: PROVISIONAL

    Source sequence(s)
    M13974
    UniProtKB/TrEMBL
    A0A3Q1MGP0
    Related
    ENSBTAP00000070362.2, ENSBTAT00000070516.2
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:342 → 600
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05616
    Location:341 → 663
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    pfam00130
    Location:102 → 152
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    21505317..21880937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005224690.5 → XP_005224747.1  protein kinase C beta type isoform X1

    See identical proteins and their annotated locations for XP_005224747.1

    UniProtKB/Swiss-Prot
    A5D7N0, P05126
    UniProtKB/TrEMBL
    A0A452DJ88
    Related
    ENSBTAP00000065659.1, ENSBTAT00000084339.2
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cl21453
    Location:341 → 664
    PKc_like; Protein Kinases, catalytic domain

  2. XM_015460312.3 → XP_015315798.1  protein kinase C beta type isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MGP0
    Related
    ENSBTAP00000027870.5, ENSBTAT00000027870.6
    Conserved Domains (4) summary
    cd04026
    Location:110 → 240
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:293 → 551
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05616
    Location:292 → 614
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    pfam00130
    Location:53 → 103
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05126.4 GenPept UniProtKB/Swiss-Prot:P05126

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.