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PRKACA protein kinase cAMP-activated catalytic subunit alpha [ Bos taurus (cattle) ]

Gene ID: 282322, updated on 5-Mar-2024

Summary

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Official Symbol
PRKACAprovided by VGNC
Official Full Name
protein kinase cAMP-activated catalytic subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:50250
See related
BGD:BT12357; Ensembl:ENSBTAG00000006642
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (11592576..11610317)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100848715 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene small integral membrane protein 46 Neighboring gene sterile alpha motif domain containing 1 Neighboring gene chromosome 7 C19orf67 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains. Hao Y, et al. Nat Commun, 2019 Sep 4. PMID 31484930, Free PMC Article
  2. Probes of the mitochondrial cAMP-dependent protein kinase. Shell JR, et al. Biochim Biophys Acta, 2013 Jul. PMID 23410952, Free PMC Article
  3. Signaling the signal, cyclic AMP-dependent protein kinase inhibition by insulin-formed H2O2 and reactivation by thioredoxin. de Piña MZ, et al. J Biol Chem, 2008 May 2. PMID 18326045
  4. Protein kinase catalytic subunit (PKAcat) from bovine lens: purification, characterization and phosphorylation of lens crystallins. Samanta B, et al. Mol Cell Biochem, 2007 Oct. PMID 17530190
  5. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Breitenlechner C, et al. Structure, 2003 Dec. PMID 14656443

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the response of the energy landscape upon cyclic AMP (cAMP) binding is domain specific of protein kinase A (PKA).
    Title: Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains.
  2. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
    Title: Cytoplasmic kinases downstream of GPR30 suppress gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone secretion from bovine anterior pituitary cells.
  3. Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.
    Title: Probes of the mitochondrial cAMP-dependent protein kinase.
  4. These data strongly suggest that H(2)O(2) promotes the formation of an intersubunit disulfide bond, impairing cAMP-dependent PKA activation.
    Title: Signaling the signal, cyclic AMP-dependent protein kinase inhibition by insulin-formed H2O2 and reactivation by thioredoxin.
  5. structural basis of selectivity for protein kinase A in complex with Rho-kinase inhibitors by x-ray crystallography
    Title: Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cAMP-dependent protein kinase catalytic subunit alpha
Names
PKA C-alpha
protein kinase, cAMP-dependent, catalytic, alpha
NP_777009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174584.2 → NP_777009.1  cAMP-dependent protein kinase catalytic subunit alpha

    See identical proteins and their annotated locations for NP_777009.1

    Status: PROVISIONAL

    Source sequence(s)
    X67154
    UniProtKB/Swiss-Prot
    P00517
    UniProtKB/TrEMBL
    A0A452DIU2
    Related
    ENSBTAP00000008727.5, ENSBTAT00000008727.5
    Conserved Domains (1) summary
    cd14209
    Location:42 → 331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    11592576..11610317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00517.3 GenPept UniProtKB/Swiss-Prot:P00517

Gene LinkOut

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