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PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Bos taurus (cattle) ]

Gene ID: 282307, updated on 5-Mar-2024

Summary

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Official Symbol
PIK3R1provided by VGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 1provided by VGNC
Primary source
VGNC:VGNC:32894
See related
Ensembl:ENSBTAG00000010989
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PIK3R1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (11395610..11491006, complement)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104975214 Neighboring gene uncharacterized LOC101902212 Neighboring gene uncharacterized LOC112443029 Neighboring gene dynein light chain 1, cytoplasmic

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The p85α regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration. Donini CF, et al. Int J Oncol, 2012 May. PMID 22366926
  2. NMR analysis of interactions of a phosphatidylinositol 3'-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites. Günther UL, et al. Biochemistry, 1996 Dec 3. PMID 8952511
  3. Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase. Booker GW, et al. Cell, 1993 May 21. PMID 7684655
  4. Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase. Booker GW, et al. Nature, 1992 Aug 20. PMID 1323062
  5. Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation. Carulla N, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19416886, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The p85alpha regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration.
    Title: The p85α regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration.
  2. The domains of p85alpha responsible for the interaction with the FTK protein network and transduction of leukemogenic signaling were identified.
    Title: Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.
  3. The effect of PIA [N6-(2-phenylisopropyl)adenosine] in p110alpha-deficient cells was attenuated effectively by both Deltap85 and betaARK-CT (beta-adrenergic receptor kinase-C-terminal peptide).
    Title: Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha
Names
PI3-kinase p85 subunit alpha
PI3-kinase regulatory subunit alpha
PI3-kinase subunit p85-alpha
PI3K regulatory subunit alpha
phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
ptdIns-3-kinase p85-alpha
ptdIns-3-kinase regulatory subunit alpha
ptdIns-3-kinase regulatory subunit p85-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174575.1 → NP_777000.1  phosphatidylinositol 3-kinase regulatory subunit alpha

    See identical proteins and their annotated locations for NP_777000.1

    Status: PROVISIONAL

    Source sequence(s)
    M61745
    UniProtKB/Swiss-Prot
    P23727
    Conserved Domains (5) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    11395610..11491006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005221436.5 → XP_005221493.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_005221493.1

    UniProtKB/Swiss-Prot
    P23727
    Conserved Domains (5) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...

  2. XM_024981213.2 → XP_024836981.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    P23727
    Conserved Domains (5) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...

  3. XM_024981214.2 → XP_024836982.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

    Conserved Domains (3) summary
    cd09930
    Location:296 → 399
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:4 → 114
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:119 → 279
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  4. XM_005221438.5 → XP_005221495.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    See identical proteins and their annotated locations for XP_005221495.1

    UniProtKB/TrEMBL
    A0A3Q1M401
    Related
    ENSBTAP00000014594.5, ENSBTAT00000014594.6
    Conserved Domains (3) summary
    cd09930
    Location:317 → 420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:25 → 135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140 → 300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  5. XM_005221437.5 → XP_005221494.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_005221494.1

    UniProtKB/TrEMBL
    A0A3Q1LW04
    Related
    ENSBTAP00000059547.2, ENSBTAT00000078857.2
    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23727.1 GenPept UniProtKB/Swiss-Prot:P23727

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