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IGFBP3 insulin like growth factor binding protein 3 [ Bos taurus (cattle) ]

Gene ID: 282261, updated on 5-Mar-2024

Summary

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Official Symbol
IGFBP3provided by VGNC
Official Full Name
insulin like growth factor binding protein 3provided by VGNC
Primary source
VGNC:VGNC:30085
See related
BGD:BT10043; Ensembl:ENSBTAG00000003994
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
IGFBP-3
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (76116379..76124833)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene microRNA mir-2420 Neighboring gene insulin like growth factor binding protein 1 Neighboring gene coiled-coil domain containing 201

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endogenous IGFBP-3 Mediates Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear Export. Agostini-Dreyer A, et al. Endocrinology, 2015 Nov. PMID 26340041
  2. Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells. Leibowitz BJ, et al. J Cell Physiol, 2009 Jul. PMID 19259947
  3. DNA polymorphism of insulin-like growth factor-binding protein-3 gene and its association with birth weight and body weight in cattle. Choudhary V, et al. J Anim Breed Genet, 2007 Feb. PMID 17302958
  4. Stimulation of insulin-like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-alpha is mediated by both phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways in mammary epithelial cells. Sivaprasad U, et al. Endocrinology, 2004 Sep. PMID 15192040
  5. A novel polymorphism in the bovine insulin-like growth factor binding protein-3 (IGFBP3) gene. Maciulla JH, et al. Anim Genet, 1997 Oct. PMID 9363609

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative analysis of IGFBP-3 gene sequence in Egyptian sheep, cattle, and buffalo shows substantial degree of homology.
    Title: Comparative analysis of IGFBP-3 gene sequence in Egyptian sheep, cattle, and buffalo.
  2. The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3.
    Title: Injectable hyaluronic acid down-regulates interferon signaling molecules, IGFBP3 and IFIT3 in the bovine intervertebral disc.
  3. These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 to the cytoplasm where it exerts its apoptotic effect.
    Title: Endogenous IGFBP-3 Mediates Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear Export.
  4. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle.
    Title: Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle.
  5. Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
    Title: Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
  6. GH, IGF-I and IGF-IBP3 regulated the growth and development traits in different growth period.
    Title: [The effects of the GH, IGF-I and IGF-IBP3 gene on growth and development traits of Nanyang cattle in different growth period].
  7. Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
    Title: Plasma insulinlike growth factor 1 and binding-protein 3 and risk of myocardial infarction in women: a prospective study.
  8. delivery of insulin-like growth factor-1 (IGF-1, delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1, its receptor (IGF-1R), and a well known IGF-1 binding protein (IGFBP-3) by articular chondrocytes
    Title: Effects of exogenous IGF-1 delivery on the early expression of IGF-1 signaling molecules by alginate embedded chondrocytes.
  9. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of IGFBP-3
    Title: Thrombospondin 1, produced by endothelial cells under the action of erythropoietin, stimulates thymidine incorporation into erythroid cells and counteracts the inhibitory action of insulin-like growth factor binding protein 3.
  10. stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK pathways in bovine mammary epithelial cells
    Title: Stimulation of insulin-like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-alpha is mediated by both phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways in mammary epithelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fibronectin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor II binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor-binding protein 3
Names
IBP-3
IGF-binding protein 3
Insulin like growth factor binding protein-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174556.1 → NP_776981.1  insulin-like growth factor-binding protein 3 precursor

    See identical proteins and their annotated locations for NP_776981.1

    Status: PROVISIONAL

    Source sequence(s)
    AF305712
    UniProtKB/Swiss-Prot
    A6QPI3, P20959, Q9GJV5
    UniProtKB/TrEMBL
    I6XXP7
    Related
    ENSBTAP00000047769.2, ENSBTAT00000053426.4
    Conserved Domains (2) summary
    smart00121
    Location:38 → 117
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:213 → 285
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    76116379..76124833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20959.3 GenPept UniProtKB/Swiss-Prot:P20959

Gene LinkOut

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