ADRA1A adrenoceptor alpha 1A [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ADRA1Aprovided by VGNC
Official Full Name: adrenoceptor alpha 1Aprovided by VGNC
Primary source: VGNC:VGNC:25693
See related: BGD:BT22464; Ensembl:ENSBTAG00000031632
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	8	NC_037335.1 (73947093..74070900, complement)

Chromosome 8 - NC_037335.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism.
Title: Hepatic glucocorticoid and α1- and β2-adrenergic receptors in calves change during neonatal maturation and are related to energy regulation.
Stimulation of transfected bovine alpha1A-AR promotes cell cycle arrest, hypertrophy and differentiation of fibroblasts into smooth muscle-like cells and expression of negative cell cycle regulators by a mechanism independent of cAMP/PKA signaling
Title: Activation of alpha1A-adrenergic receptor promotes differentiation of rat-1 fibroblasts to a smooth muscle-like phenotype.
modeling of full-length alpha(1a) adrenergic receptor due to its biological role and significant implications in pharmacological treatment of benign prostate hyperplasia
Title: Binding site analysis of full-length alpha1a adrenergic receptor using homology modeling and molecular docking.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables alpha1-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alpha-1A adrenergic receptor

Names: adrenergic, alpha-1A-, receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174498.2 → NP_776923.1 alpha-1A adrenergic receptor

See identical proteins and their annotated locations for NP_776923.1

Status: PROVISIONAL

Source sequence(s)

J05426

UniProtKB/Swiss-Prot

P18130

Related

ENSBTAP00000042306.3, ENSBTAT00000044849.5

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

Range

73947093..74070900 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024995490.2 → XP_024851258.1 alpha-1A adrenergic receptor isoform X3

UniProtKB/TrEMBL

A0A3Q1MMS4

Related

ENSBTAP00000070757.1, ENSBTAT00000073624.2

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_059888964.1 → XP_059744947.1 alpha-1A adrenergic receptor isoform X2

Related

ENSBTAP00000072803.1, ENSBTAT00000086316.2
XM_024995487.2 → XP_024851255.1 alpha-1A adrenergic receptor isoform X1

UniProtKB/TrEMBL

F1MYI6

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors