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ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Bos taurus (cattle) ]

Gene ID: 282041, updated on 3-Apr-2024

Summary

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Official Symbol
ROCK2provided by VGNC
Official Full Name
Rho associated coiled-coil containing protein kinase 2provided by VGNC
Primary source
VGNC:VGNC:34082
See related
Ensembl:ENSBTAG00000005847
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ROCK-II
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (86489043..86617614)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene E2F transcription factor 6 Neighboring gene histone H4-like Neighboring gene solute carrier family 66 member 3 Neighboring gene chromosome 11 C2orf50 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). Amano M, et al. J Biol Chem, 1996 Aug 23. PMID 8702756
  2. RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability. Clements RT, et al. Am J Physiol Lung Cell Mol Physiol, 2005 Feb. PMID 15475381
  3. Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase. Shimizu T, et al. J Biol Chem, 2003 Nov 14. PMID 12954645
  4. Isolation and partial sequence of bovine cDNA clones for the high-mobility-group protein (HMG-1). Pentecost B, et al. Biosci Rep, 1984 Jan. PMID 6141822
  5. The Rho-associated protein kinase p160ROCK is required for centrosome positioning. Chevrier V, et al. J Cell Biol, 2002 May 27. PMID 12034773, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rho-kinase analysis of coiled-coil association of the RhoA-binding domain
    Title: Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase.
  2. nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity
    Title: Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.
  3. RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.
    Title: RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho-associated protein kinase 2
Names
p164 ROCK-2
rho-associated, coiled-coil-containing protein kinase 2
rho-associated, coiled-coil-containing protein kinase II
NP_776877.1
XP_059747003.1
XP_059747004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174452.2 → NP_776877.1  rho-associated protein kinase 2

    See identical proteins and their annotated locations for NP_776877.1

    Status: PROVISIONAL

    Source sequence(s)
    U36909
    UniProtKB/Swiss-Prot
    Q28021
    UniProtKB/TrEMBL
    F1N319
    Related
    ENSBTAP00000091400.1, ENSBTAT00000112825.1
    Conserved Domains (7) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:92 → 354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:437 → 1101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1261 → 1307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1151 → 1257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    pfam08912
    Location:979 → 1046
    Rho_Binding; Rho Binding

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    86489043..86617614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059891020.1 → XP_059747003.1  rho-associated protein kinase 2 isoform X1

  2. XM_059891021.1 → XP_059747004.1  rho-associated protein kinase 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28021.1 GenPept UniProtKB/Swiss-Prot:Q28021

Gene LinkOut

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Research Materials
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