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PLCB4 phospholipase C beta 4 [ Bos taurus (cattle) ]

Gene ID: 281985, updated on 3-Apr-2024

Summary

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Official Symbol
PLCB4provided by VGNC
Official Full Name
phospholipase C beta 4provided by VGNC
Primary source
VGNC:VGNC:32983
See related
BGD:BT13437; Ensembl:ENSBTAG00000013116
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (2021105..2503504)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 1 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC112449370 Neighboring gene uncharacterized LOC112449364 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene p21 (RAC1) activated kinase 5 Neighboring gene small nucleolar RNA SNORA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification of a novel phospholipase C isozyme from bovine cerebellum. Min DS, et al. J Biol Chem, 1993 Jun 5. PMID 8389372
  2. Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila. Ferreira PA, et al. Proc Natl Acad Sci U S A, 1993 Jul 1. PMID 8327481, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Names
PCL-C1
PLC-beta-4
phosphoinositide phospholipase C
phosphoinositide phospholipase C-beta-4
NP_001159982.1
XP_024856078.1
XP_024856079.1
XP_024856080.1
XP_024856081.1
XP_024856082.1
XP_024856083.1
XP_024856084.1
XP_024856085.1
XP_024856086.1
XP_024856087.1
XP_024856088.1
XP_059748372.1
XP_059748373.1
XP_059748374.1
XP_059748375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166510.2 → NP_001159982.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000013
    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    UniProtKB/TrEMBL
    F1MSD7
    Related
    ENSBTAP00000091944.1, ENSBTAT00000118155.1
    Conserved Domains (6) summary
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:839 → 1157
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    2021105..2503504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000312.2 → XP_024856080.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Related
    ENSBTAP00000071384.2, ENSBTAT00000082032.2
    Conserved Domains (6) summary
    cd00275
    Location:720 → 836
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 686
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:23 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:932 → 973
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:154 → 306
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:857 → 1175
    Neuromodulin_N; Gap junction protein N-terminal region

  2. XM_059892392.1 → XP_059748375.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    UniProtKB/TrEMBL
    F1MSD7

  3. XM_025000311.2 → XP_024856079.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (6) summary
    cd00275
    Location:720 → 836
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 686
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:23 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:932 → 973
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:154 → 306
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:857 → 1175
    Neuromodulin_N; Gap junction protein N-terminal region

  4. XM_025000314.2 → XP_024856082.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Related
    ENSBTAP00000017447.7, ENSBTAT00000017447.7
    Conserved Domains (6) summary
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:851 → 1169
    Neuromodulin_N; Gap junction protein N-terminal region

  5. XM_025000316.2 → XP_024856084.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    UniProtKB/TrEMBL
    F1MSD7
    Related
    ENSBTAP00000100801.1, ENSBTAT00000101096.1
    Conserved Domains (6) summary
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:839 → 1157
    Neuromodulin_N; Gap junction protein N-terminal region

  6. XM_059892391.1 → XP_059748374.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

  7. XM_059892390.1 → XP_059748373.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

  8. XM_059892389.1 → XP_059748372.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

  9. XM_025000318.2 → XP_024856086.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (6) summary
    cd00275
    Location:720 → 836
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 686
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:23 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:932 → 973
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:154 → 306
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:857 → 1188
    Neuromodulin_N; Gap junction protein N-terminal region

  10. XM_025000319.2 → XP_024856087.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (6) summary
    cd00275
    Location:708 → 824
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 674
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:23 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:920 → 961
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:154 → 306
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:845 → 1176
    Neuromodulin_N; Gap junction protein N-terminal region

  11. XM_025000317.2 → XP_024856085.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (7) summary
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:300 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:23 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)
    cd15898
    Location:171 → 199
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26511
    Location:839 → 1157
    Neuromodulin_N; Gap junction protein N-terminal region
    cl28895
    Location:155 → 288
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  12. XM_025000310.2 → XP_024856078.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (6) summary
    cd00275
    Location:720 → 836
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 686
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:23 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:932 → 973
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:154 → 306
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:857 → 1175
    Neuromodulin_N; Gap junction protein N-terminal region

  13. XM_025000315.2 → XP_024856083.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (6) summary
    cd00275
    Location:708 → 824
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:318 → 674
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:23 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:920 → 961
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:154 → 306
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:845 → 1163
    Neuromodulin_N; Gap junction protein N-terminal region

  14. XM_025000313.2 → XP_024856081.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (6) summary
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:851 → 1169
    Neuromodulin_N; Gap junction protein N-terminal region

  15. XM_025000320.2 → XP_024856088.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8

    UniProtKB/Swiss-Prot
    Q07721, Q07722, Q07723, Q07724
    Conserved Domains (5) summary
    cd00275
    Location:571 → 687
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:169 → 537
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    pfam06631
    Location:783 → 824
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:5 → 157
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:708 → 1026
    Neuromodulin_N; Gap junction protein N-terminal region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_174424.1: Suppressed sequence

    Description
    NM_174424.1: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07722.1 GenPept UniProtKB/Swiss-Prot:Q07722

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