U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IRAG1 inositol 1,4,5-triphosphate receptor associated 1 [ Bos taurus (cattle) ]

Gene ID: 281918, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
IRAG1
Gene description
inositol 1,4,5-triphosphate receptor associated 1
See related
BGD:BT14004; Ensembl:ENSBTAG00000007129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
IRAG; MRVI1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 15
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (41972367..42098627)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL42-like Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene ring finger protein 141 Neighboring gene microRNA mir-2315

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Desch M, et al. Cardiovasc Res, 2010 Jun 1. PMID 20080989
  2. Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Schlossmann J, et al. Nature, 2000 Mar 9. PMID 10724174
  3. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. Casteel DE, et al. J Biol Chem, 2005 Nov 18. PMID 16166082
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cGKIbeta signaling via IRAG is essential for regulation of smooth muscle tone and of intracellular calcium by NO and by atrial natriuretic peptide.
    Title: IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation.
  2. cGMP-dependent protein kinase Ibeta binds to TFII-I and IRAG through a common interaction motif
    Title: Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
inositol 1,4,5-triphosphate receptor associated 1
Names
IP3 receptor associated cGMP kinase substrate
JAW1-related protein MRVI1
inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
murine retrovirus integration site 1 homolog
protein MRVI1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174392.4 → NP_776817.2  inositol 1,4,5-triphosphate receptor associated 1 isoform a

    See identical proteins and their annotated locations for NP_776817.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    NKLS02000015
    UniProtKB/Swiss-Prot
    Q9N1E9, Q9N1F0
    UniProtKB/TrEMBL
    F1MH42
    Related
    ENSBTAP00000009387.6, ENSBTAT00000009387.7
    Conserved Domains (1) summary
    pfam05781
    Location:325 → 911
    MRVI1; MRVI1 protein

  2. NM_194465.4 → NP_919447.2  inositol 1,4,5-triphosphate receptor associated 1 isoform b

    See identical proteins and their annotated locations for NP_919447.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' end exon compared to transcript variant 1, resulting in translation initiation from an in-frame, downstream AUG, and an isoform (b) with a shorter N-terminus compared to isoform a.
    Source sequence(s)
    NKLS02000015
    UniProtKB/TrEMBL
    A0A3Q1LZ96, F1MYA5
    Conserved Domains (1) summary
    pfam05781
    Location:273 → 859
    MRVI1; MRVI1 protein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    41972367..42098627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005215898.5 → XP_005215955.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9N1E9, Q9N1F0
    Related
    ENSBTAP00000043465.4, ENSBTAT00000046140.5
    Conserved Domains (1) summary
    pfam05781
    Location:326 → 912
    MRVI1; MRVI1 protein

  2. XM_005215900.5 → XP_005215957.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LZ96
    Conserved Domains (1) summary
    pfam05781
    Location:274 → 860
    MRVI1; MRVI1 protein

  3. XM_024974996.2 → XP_024830764.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X5

    UniProtKB/TrEMBL
    A8E656
    Conserved Domains (1) summary
    pfam05781
    Location:11 → 597
    MRVI1; MRVI1 protein

  4. XM_024974998.2 → XP_024830766.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X5

    UniProtKB/TrEMBL
    A8E656
    Conserved Domains (1) summary
    pfam05781
    Location:11 → 597
    MRVI1; MRVI1 protein

  5. XM_059874559.1 → XP_059730542.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

  6. XM_024974995.2 → XP_024830763.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1LZ96
    Related
    ENSBTAP00000061020.1, ENSBTAT00000084912.2
    Conserved Domains (1) summary
    pfam05781
    Location:259 → 845
    MRVI1; MRVI1 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N1F0.1 GenPept UniProtKB/Swiss-Prot:Q9N1F0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous