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GNAS GNAS complex locus [ Bos taurus (cattle) ]

Gene ID: 281793, updated on 4-Apr-2024

Summary

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Official Symbol
GNASprovided by VGNC
Official Full Name
GNAS complex locusprovided by VGNC
Primary source
VGNC:VGNC:108130
See related
BGD:BT12337; Ensembl:ENSBTAG00000047223 Ensembl:ENSBTAG00000052413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SCG6; GNAS1; NESP55
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (57465317..57532620, complement)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene cathepsin Z Neighboring gene negative elongation factor complex member C/D Neighboring gene uncharacterized LOC132346936 Neighboring gene uncharacterized LOC101909083 Neighboring gene uncharacterized LOC107133071 Neighboring gene microRNA mir-6123 Neighboring gene microRNA mir-296

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β(1)-Adrenergic Receptor. Su M, et al. Mol Cell, 2020 Oct 1. PMID 32818430, Free PMC Article
  2. Imprinting of Nesp55 gene in cattle. Khatib H. Mamm Genome, 2004 Aug. PMID 15457345
  3. Galpha(s) is palmitoylated at the N-terminal glycine. Kleuss C, et al. EMBO J, 2003 Feb 17. PMID 12574119, Free PMC Article
  4. Crystal structure of the adenylyl cyclase activator Gsalpha. Sunahara RK, et al. Science, 1997 Dec 12. PMID 9395396
  5. Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Robishaw JD, et al. Proc Natl Acad Sci U S A, 1986 Mar. PMID 3081893, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta1-Adrenergic Receptor.
    Title: Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β(1)-Adrenergic Receptor.
  2. application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor
    Title: Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
  3. crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor and nucleotide-free Gs heterotrimer
    Title: Crystal structure of the β2 adrenergic receptor-Gs protein complex.
  4. the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex
    Title: DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits.
  5. a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+
    Title: Copper and zinc inhibit Galphas function: a nucleotide-free state of Galphas induced by Cu2+ and Zn2+.
  6. maternally expressed like its counterparts in mouse and human
    Title: Imprinting of Nesp55 gene in cattle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC148689, MGC152036

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-2 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables corticotropin-releasing hormone receptor 1 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mu-type opioid receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to parathyroid hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sensory perception of chemical stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GNAS complex locus; SCG6 (secretogranin VI)
Names
adenylate cyclase-stimulating G alpha protein
guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
neuroendocrine secretory protein 55
secretogranin VI
stimulatory G-protein alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271771.1 → NP_001258700.1  SCG6 (secretogranin VI) isoform SCG6 precursor

    See identical proteins and their annotated locations for NP_001258700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is maternally expressed and encodes secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. Its coding region is within the 5'-most exon and does not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript, GNAS-AS1.
    Source sequence(s)
    BC102905, DV819537, DV875704, DV882459
    UniProtKB/Swiss-Prot
    O18979
    Conserved Domains (1) summary
    pfam06390
    Location:1 → 241
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

  2. NM_181021.3 → NP_851364.1  GNAS complex locus isoform GNASL

    See identical proteins and their annotated locations for NP_851364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is biallelically expressed and encodes guanine nucleotide binding protein alpha s long (GNASL), also known as alpha-S2, a form of the G-protein alpha subunit.
    Source sequence(s)
    BC122757
    UniProtKB/Swiss-Prot
    P04896, Q0II85, Q3SZE7
    Related
    ENSBTAP00000094718.1, ENSBTAT00000112874.1
    Conserved Domains (1) summary
    cd00066
    Location:41 → 388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    57465317..57532620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059892388.1 → XP_059748371.1  GNAS complex locus isoform X13

  2. XM_059892385.1 → XP_059748368.1  GNAS complex locus isoform X4

  3. XM_059892384.1 → XP_059748367.1  GNAS complex locus isoform X3

    Related
    ENSBTAP00000097346.1, ENSBTAT00000110331.1

  4. XM_059892383.1 → XP_059748366.1  GNAS complex locus isoform X2

  5. XM_059892382.1 → XP_059748365.1  GNAS complex locus isoform X1

    Related
    ENSBTAP00000023246.7, ENSBTAT00000023246.7

  6. XM_025000300.2 → XP_024856068.1  GNAS complex locus isoform X11

    Conserved Domains (1) summary
    cd00066
    Location:1 → 314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  7. XM_059892387.1 → XP_059748370.1  GNAS complex locus isoform X10

  8. XM_025000297.2 → XP_024856065.1  GNAS complex locus isoform X9

    Conserved Domains (1) summary
    cd00066
    Location:1 → 329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  9. XM_059892386.1 → XP_059748369.1  GNAS complex locus isoform X8

  10. XM_025000296.2 → XP_024856064.1  GNAS complex locus isoform X7

    Conserved Domains (1) summary
    cd00066
    Location:41 → 373
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  11. XM_025000295.2 → XP_024856063.1  GNAS complex locus isoform X6

    Conserved Domains (1) summary
    cd00066
    Location:41 → 374
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  12. XM_025000294.2 → XP_024856062.1  GNAS complex locus isoform X5

    Related
    ENSBTAP00000072381.2, ENSBTAT00000070189.2
    Conserved Domains (1) summary
    cd00066
    Location:41 → 389
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  13. XM_025000303.2 → XP_024856071.1  SCG6 (secretogranin VI) isoform X12

    UniProtKB/TrEMBL
    A6QPC1, F1N0T0
    Related
    ENSBTAP00000054341.2, ENSBTAT00000064670.3
    Conserved Domains (1) summary
    pfam06390
    Location:1 → 241
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18979.1 GenPept UniProtKB/Swiss-Prot:O18979
P04896.1 GenPept UniProtKB/Swiss-Prot:P04896

Gene LinkOut

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