EDNRA endothelin receptor type A [Bos taurus (cattle)] - Gene

Summary

Official Symbol: EDNRAprovided by VGNC
Official Full Name: endothelin receptor type Aprovided by VGNC
Primary source: VGNC:VGNC:28329
See related: BGD:BT25051; Ensembl:ENSBTAG00000013674
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	17	NC_037344.1 (10596771..10669858, complement)

Chromosome 17 - NC_037344.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
Title: Endothelin as a local regulating factor in the bovine oviduct.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Title: Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy.
Elevated local expression of ET-1 and Ednra/Ednrb during the peri-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Title: Endothelin-1 system in the bovine oviduct: a regulator of local contraction and gamete transport.
Brain microvessel endothelin type A receptors are coupled to ceramide production.
Title: Brain microvessel endothelin type A receptors are coupled to ceramide production.
ET receptors in pigment cells of vertebrate species were identified by RT-PCR assays, and the differential expression of the various subtypes in each species was compared by quantitative PCR.
Title: Expression of endothelin receptors in frog, chicken, mouse and human pigment cells.

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General gene information

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Markers

EDNRA (e-PCR)
- UniSTS:278328

SHGC-59477 (e-PCR)
- UniSTS:25684

MARC_39089-39090:1074886320:3 (e-PCR)
- UniSTS:467337

MARC_39095-39096:1074887725:1 (e-PCR)
- UniSTS:467340

MARC_39097-39098:1074887924:1 (e-PCR)
- UniSTS:467341

MARC_39103-39104:1074888564:1 (e-PCR)
- UniSTS:467343

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endothelin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelin-1 receptor

Names: ET-A; ET-AR; endothelin A receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174308.2 → NP_776733.1 endothelin-1 receptor precursor

See identical proteins and their annotated locations for NP_776733.1

Status: PROVISIONAL

Source sequence(s)

X57765

UniProtKB/Swiss-Prot

A3KMY5, A5PK08, P21450

Related

ENSBTAP00000018173.5, ENSBTAT00000018173.7

Conserved Domains (1) summary

cd15975
Location:81 → 380

7tmA_ET-AR; endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors