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NPR2 natriuretic peptide receptor 2 [ Bos taurus (cattle) ]

Gene ID: 281357, updated on 3-Apr-2024

Summary

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Official Symbol
NPR2provided by VGNC
Official Full Name
natriuretic peptide receptor 2provided by VGNC
Primary source
VGNC:VGNC:106847
See related
BGD:BT10172; Ensembl:ENSBTAG00000011434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (59956172..59974871)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosylceramidase beta 2 Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene sperm associated antigen 8 Neighboring gene histidine triad nucleotide binding protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a G protein-coupled guanylyl cyclase-B receptor from bovine tracheal smooth muscle. Alfonzo MJ, et al. J Recept Signal Transduct Res, 2006. PMID 16818377
  2. Cloning and functional expression of the bovine natriuretic peptide receptor-B (natriuretic factor R1c subtype. Fenrick R, et al. Mol Cell Biochem, 1994 Aug 31. PMID 7845391
  3. [Detection of expression of a membrane form of the guanylate cyclase type of GC-B in cattle retina]. Shmukler BE, et al. Bioorg Khim, 1993 Jun. PMID 8103329
  4. Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP. Antos LK, et al. Am J Physiol Endocrinol Metab, 2007 Dec. PMID 17848634
  5. Coupling of M3 acetylcholine receptor to Gq16 activates a natriuretic peptide receptor guanylyl cyclase. Bruges G, et al. J Recept Signal Transduct Res, 2007. PMID 17613728

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data support the existence of a novel transducing cascade, involving Galpha(q16)beta gamma coupling M(3)AChR to NPR-GC.
    Title: Coupling of M3 acetylcholine receptor to Gq16 activates a natriuretic peptide receptor guanylyl cyclase.
  2. ATP is not required for the initial activation of natriuretic peptide receptor A and B, but does increase activity over time by reducing the apparent K(m) for GTP.
    Title: Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP.
  3. NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors
    Title: Characterization of a G protein-coupled guanylyl cyclase-B receptor from bovine tracheal smooth muscle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables natriuretic peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
atrial natriuretic peptide receptor 2
Names
ANP-B
ANPR-B
ANPRB
GC-B
NPR-B
atrial natriuretic peptide B-type receptor
atrial natriuretic peptide receptor B
atrial natriuretic peptide receptor type B
atrionatriuretic peptide receptor B
guanylate cyclase B
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
NP_776551.1
XP_024851210.1
XP_024851211.1
XP_024851212.1
XP_059744929.1
XP_059744930.1
XP_059744931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174126.2 → NP_776551.1  atrial natriuretic peptide receptor 2 precursor

    See identical proteins and their annotated locations for NP_776551.1

    Status: PROVISIONAL

    Source sequence(s)
    L26359
    UniProtKB/Swiss-Prot
    P46197
    UniProtKB/TrEMBL
    A0A3Q1M4P0
    Related
    ENSBTAP00000015204.7, ENSBTAT00000015204.7
    Conserved Domains (4) summary
    smart00044
    Location:825 → 1009
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:518 → 792
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:801 → 846
    HNOBA; Heme NO binding associated
    cl10011
    Location:26 → 421
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    59956172..59974871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888946.1 → XP_059744929.1  atrial natriuretic peptide receptor 2 isoform X1

  2. XM_059888947.1 → XP_059744930.1  atrial natriuretic peptide receptor 2 isoform X3

  3. XM_024995442.2 → XP_024851210.1  atrial natriuretic peptide receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M4P0
    Related
    ENSBTAP00000068560.2, ENSBTAT00000080254.2
    Conserved Domains (4) summary
    smart00044
    Location:859 → 1043
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:552 → 826
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:835 → 880
    HNOBA; Heme NO binding associated
    cl10011
    Location:26 → 455
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  4. XM_024995443.2 → XP_024851211.1  atrial natriuretic peptide receptor 2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1M4P0
    Conserved Domains (4) summary
    smart00044
    Location:834 → 1018
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:520 → 801
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:810 → 855
    HNOBA; Heme NO binding associated
    cl10011
    Location:26 → 455
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  5. XM_059888948.1 → XP_059744931.1  atrial natriuretic peptide receptor 2 isoform X5

  6. XM_024995444.2 → XP_024851212.1  atrial natriuretic peptide receptor 2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1M4P0, G3N2S3
    Related
    ENSBTAP00000056191.3, ENSBTAT00000065432.3
    Conserved Domains (4) summary
    smart00044
    Location:800 → 984
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:486 → 767
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:776 → 821
    HNOBA; Heme NO binding associated
    cl10011
    Location:26 → 421
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46197.1 GenPept UniProtKB/Swiss-Prot:P46197

Gene LinkOut

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