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IGF1 insulin like growth factor 1 [ Bos taurus (cattle) ]

Gene ID: 281239, updated on 3-Apr-2024

Summary

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Official Symbol
IGF1provided by VGNC
Official Full Name
insulin like growth factor 1provided by VGNC
Primary source
VGNC:VGNC:30076
See related
BGD:BT11525; Ensembl:ENSBTAG00000011082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
IGF-1; IGF-I
Orthologs
human mouse all
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Genomic context

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See IGF1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (66186011..66264048, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene reticulon-3-like Neighboring gene T-complex protein 1 subunit epsilon-like Neighboring gene uncharacterized LOC112446717 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC101902701

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis]. Martens H. Tierarztl Prax Ausg G Grosstiere Nutztiere, 2023 Apr. PMID 37230145
  2. Polymorphism of Insulin-like Growth Factor 1 Gene (IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia. Yurnalis, et al. Pak J Biol Sci, 2017. PMID 29023078
  3. Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling. Lu Y, et al. Am J Physiol Regul Integr Comp Physiol, 2017 May 1. PMID 28228415, Free PMC Article
  4. Transcriptomics of liver and muscle in Holstein cows genetically divergent for fertility highlight differences in nutrient partitioning and inflammation processes. Moran B, et al. BMC Genomics, 2016 Aug 11. PMID 27514375, Free PMC Article
  5. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle. Chung HY, et al. Genet Mol Res, 2015 Apr 10. PMID 25966067

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].
    Title: [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].
  2. Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
    Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
  3. Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
    Title: Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
  4. the addition of PAPP-A did not affect embryo yield and blastocyst survival, higher IGF-1 levels may affect embryo competence through differential expression of genes involved in lipid metabolism, oocyte competence, and mitochondrial function.
    Title: Use of pregnancy-associated plasma protein-A during oocyte in vitro maturation increases IGF-1 and affects the transcriptional profile of cumulus cells and embryos from Nelore cows.
  5. This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility.
    Title: Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows.
  6. LncRNA H19 participated in the regulation of the proliferation and apoptosis of male germline stem cells via the IGF-1 signaling pathway
    Title: H19 regulates the proliferation of bovine male germline stem cells via IGF-1 signaling pathway.
  7. plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves
    Title: Relationships of plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I concentrations with scrotal circumference and testicular weight in Japanese Black beef bull calves.
  8. These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.
    Title: Plasma IGF-I, INSL3, testosterone, inhibin concentrations and scrotal circumferences surrounding puberty in Japanese Black beef bulls with normal and abnormal semen.
  9. IGF1/RsaI was associated with average daily weight gain in cattle.
    Title: Polymorphism of Insulin-like Growth Factor 1 Gene (IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia.
  10. Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
    Title: Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor I
Names
class 1 insulin-like growth factor I preproprotein
insulin growth factor-1
insulin-like growth factor 1 (somatomedin C)
insulin-like growth factor I (somatomedin C)
prepro-IGF-I
somatomedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077828.1 → NP_001071296.1  insulin-like growth factor I preproprotein

    See identical proteins and their annotated locations for NP_001071296.1

    Status: PROVISIONAL

    Source sequence(s)
    BC126802
    UniProtKB/Swiss-Prot
    P07455
    UniProtKB/TrEMBL
    F2X2F0, Q9N1C1
    Related
    ENSBTAP00000082984.1, ENSBTAT00000103741.1
    Conserved Domains (1) summary
    cd04368
    Location:50 → 117
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    66186011..66264048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005206497.5 → XP_005206554.1  insulin-like growth factor I isoform X5

    See identical proteins and their annotated locations for XP_005206554.1

    UniProtKB/TrEMBL
    Q9N1C1
    Related
    ENSBTAP00000014713.6, ENSBTAT00000014713.7
    Conserved Domains (1) summary
    cd04368
    Location:49 → 116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  2. XM_005206499.5 → XP_005206556.1  insulin-like growth factor I isoform X7

    See identical proteins and their annotated locations for XP_005206556.1

    UniProtKB/TrEMBL
    F2X2F2, Q9N1C1
    Conserved Domains (1) summary
    cd04368
    Location:34 → 101
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  3. XM_005206500.5 → XP_005206557.1  insulin-like growth factor I isoform X8

    See identical proteins and their annotated locations for XP_005206557.1

    UniProtKB/TrEMBL
    Q9N1C1
    Conserved Domains (1) summary
    cd04368
    Location:33 → 100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  4. XM_059886094.1 → XP_059742077.1  insulin-like growth factor I isoform X1

    UniProtKB/TrEMBL
    F2X2F1

  5. XM_024991342.2 → XP_024847110.1  insulin-like growth factor I isoform X6

    Conserved Domains (1) summary
    cd04368
    Location:50 → 117
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

  6. XM_015471064.3 → XP_015326550.1  insulin-like growth factor I isoform X4

    Conserved Domains (2) summary
    cd04368
    Location:33 → 100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam15724
    Location:108 → 157
    TMEM119; TMEM119 family

  7. XM_015471062.3 → XP_015326548.1  insulin-like growth factor I isoform X2

    Related
    ENSBTAP00000055243.2, ENSBTAT00000063328.3
    Conserved Domains (2) summary
    cd04368
    Location:49 → 116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam15724
    Location:124 → 173
    TMEM119; TMEM119 family

  8. XM_015471061.3 → XP_015326547.1  insulin-like growth factor I isoform X1

    UniProtKB/TrEMBL
    F2X2F1
    Conserved Domains (2) summary
    cd04368
    Location:50 → 117
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam15724
    Location:125 → 174
    TMEM119; TMEM119 family

  9. XM_015471063.3 → XP_015326549.1  insulin-like growth factor I isoform X3

    UniProtKB/TrEMBL
    F2X2F3
    Related
    ENSBTAP00000041154.3, ENSBTAT00000043595.4
    Conserved Domains (2) summary
    cd04368
    Location:34 → 101
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam15724
    Location:109 → 158
    TMEM119; TMEM119 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07455.2 GenPept UniProtKB/Swiss-Prot:P07455

Gene LinkOut

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