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GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 [ Bos taurus (cattle) ]

Gene ID: 281216, updated on 5-Mar-2024

Summary

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Official Symbol
GUCY1A1provided by VGNC
Official Full Name
guanylate cyclase 1 soluble subunit alpha 1provided by VGNC
Primary source
VGNC:VGNC:29720
See related
BGD:BT14963; Ensembl:ENSBTAG00000014576
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GUCY1A3
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (43601204..43673358, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit family member 5 Neighboring gene guanylate cyclase 1 soluble subunit beta 1 Neighboring gene uncharacterized LOC101904168 Neighboring gene uncharacterized LOC104970268

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. First 3D-Structural Data of Full-Length Guanylyl Cyclase 1 in Rod-Outer-Segment Preparations of Bovine Retina by Cross-Linking/Mass Spectrometry. Rehkamp A, et al. J Mol Biol, 2021 May 14. PMID 33744315
  2. The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. Homology between the two subunits of the enzyme. Koesling D, et al. FEBS Lett, 1990 Jun 18. PMID 1973124
  3. Dimerization of nitric oxide-sensitive guanylyl cyclase requires the alpha 1 N terminus. Wagner C, et al. J Biol Chem, 2005 May 6. PMID 15749699
  4. Quaternary structure controls ligand dynamics in soluble guanylate cyclase. Yoo BK, et al. J Biol Chem, 2012 Feb 24. PMID 22223482, Free PMC Article
  5. Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis. Liu Y, et al. Proc Natl Acad Sci U S A, 1997 Dec 9. PMID 9391039, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. First 3D-Structural Data of Full-Length Guanylyl Cyclase 1 in Rod-Outer-Segment Preparations of Bovine Retina by Cross-Linking/Mass Spectrometry.
    Title: First 3D-Structural Data of Full-Length Guanylyl Cyclase 1 in Rod-Outer-Segment Preparations of Bovine Retina by Cross-Linking/Mass Spectrometry.
  2. We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain.
    Title: Quaternary structure controls ligand dynamics in soluble guanylate cyclase.
  3. The N-terminal region of nitric oxide-sensitive guanylyl cyclase alpha 1 subunit(amino acids 61-128) is mandatory for quantitative dimerization.
    Title: Dimerization of nitric oxide-sensitive guanylyl cyclase requires the alpha 1 N terminus.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxygen levels IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of guanylate cyclase complex, soluble IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanylate cyclase soluble subunit alpha-1
Names
GCS-alpha-1
NO-sensitive GC alpha 1 subunit
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase soluble subunit alpha-3
larger subunit of soluble guanylyl cyclase
nitric oxide-sensitive guanylyl cyclase alpha 1 subunit
soluble guanylate cyclase large subunit
NP_786972.1
XP_005217697.1
XP_005217698.1
XP_005217699.1
XP_005217700.1
XP_024832768.1
XP_024832769.1
XP_059731851.1
XP_059731852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175778.2 → NP_786972.1  guanylate cyclase soluble subunit alpha-1

    See identical proteins and their annotated locations for NP_786972.1

    Status: PROVISIONAL

    Source sequence(s)
    X54014
    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
    Related
    ENSBTAP00000064987.1, ENSBTAT00000074007.1
    Conserved Domains (3) summary
    pfam00211
    Location:473 → 644
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:117 → 235
    HNOB; Haem-NO-binding
    pfam07701
    Location:278 → 467
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43601204..43673358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005217642.5 → XP_005217699.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_005217699.1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
    Related
    ENSBTAP00000019398.5, ENSBTAT00000019398.6
    Conserved Domains (3) summary
    pfam00211
    Location:473 → 644
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:117 → 235
    HNOB; Haem-NO-binding
    pfam07701
    Location:278 → 467
    HNOBA; Heme NO binding associated

  2. XM_005217641.5 → XP_005217698.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_005217698.1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
    Conserved Domains (3) summary
    pfam00211
    Location:473 → 644
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:117 → 235
    HNOB; Haem-NO-binding
    pfam07701
    Location:278 → 467
    HNOBA; Heme NO binding associated

  3. XM_024977000.2 → XP_024832768.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
    Conserved Domains (3) summary
    pfam00211
    Location:473 → 644
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:117 → 235
    HNOB; Haem-NO-binding
    pfam07701
    Location:278 → 467
    HNOBA; Heme NO binding associated

  4. XM_005217643.5 → XP_005217700.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_005217700.1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
    Conserved Domains (3) summary
    pfam00211
    Location:473 → 644
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:117 → 235
    HNOB; Haem-NO-binding
    pfam07701
    Location:278 → 467
    HNOBA; Heme NO binding associated

  5. XM_059875869.1 → XP_059731852.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44

  6. XM_005217640.5 → XP_005217697.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_005217697.1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
    Conserved Domains (3) summary
    pfam00211
    Location:473 → 644
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:117 → 235
    HNOB; Haem-NO-binding
    pfam07701
    Location:278 → 467
    HNOBA; Heme NO binding associated

  7. XM_024977001.2 → XP_024832769.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
    Conserved Domains (3) summary
    pfam00211
    Location:473 → 644
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:117 → 235
    HNOB; Haem-NO-binding
    pfam07701
    Location:278 → 467
    HNOBA; Heme NO binding associated

  8. XM_059875868.1 → XP_059731851.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    UniProtKB/Swiss-Prot
    P19687
    UniProtKB/TrEMBL
    A0A1P8NW44
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19687.1 GenPept UniProtKB/Swiss-Prot:P19687

Gene LinkOut

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