U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Exosc5 exosome component 5 [ Mus musculus (house mouse) ]

Gene ID: 27998, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Exosc5provided by MGI
Official Full Name
exosome component 5provided by MGI
Primary source
MGI:MGI:107889
See related
Ensembl:ENSMUSG00000061286 AllianceGenome:MGI:107889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Wsu180e
Summary
Predicted to enable RNA binding activity. Acts upstream of or within RNA catabolic process. Predicted to be located in nucleoplasm and transcriptionally active chromatin. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Predicted to be active in nucleolus. Is expressed in embryo and extraembryonic component. Orthologous to human EXOSC5 (exosome component 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 168.2), adrenal adult (RPKM 45.2) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 A3; 7 13.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25358578..25367457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25659153..25668032)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57782 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E8156 Neighboring gene STARR-positive B cell enhancer ABC_E10430 Neighboring gene STARR-seq mESC enhancer starr_18309 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26443819-26444002 Neighboring gene STARR-positive B cell enhancer ABC_E696 Neighboring gene transmembrane protein 91 Neighboring gene STARR-positive B cell enhancer ABC_E9022 Neighboring gene STARR-positive B cell enhancer ABC_E6524 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26466931-26467040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26468633-26468786 Neighboring gene B9 protein domain 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Flynn RA, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670248, Free PMC Article
  2. Tissue-specific expression and mapping of the Cox7ah gene in mouse. Jaradat SA, et al. Genomics, 1998 May 1. PMID 9615220
  3. Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Ulmke PA, et al. Development, 2021 Feb 8. PMID 33462115, Free PMC Article
  4. Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout. Hildebrandt MR, et al. Dev Biol, 2019 Nov 15. PMID 31330130
  5. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA deamination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within RNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
exosome complex component RRP46
Names
exosome complex exonuclease RRP46
ribosomal RNA-processing protein 46

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138586.3 → NP_613052.1  exosome complex component RRP46

    See identical proteins and their annotated locations for NP_613052.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AK006475, BB856072, BE854983, BY198385
    Consensus CDS
    CCDS20990.1
    UniProtKB/Swiss-Prot
    Q8K1J2, Q9CRA8
    UniProtKB/TrEMBL
    Q3U2K4
    Related
    ENSMUSP00000078580.7, ENSMUST00000079634.8
    Conserved Domains (2) summary
    TIGR02065
    Location:11 → 232
    ECX1; archaeal exosome-like complex exonuclease 1
    cd11372
    Location:28 → 225
    RNase_PH_RRP46; RRP46 subunit of eukaryotic exosome

RNA

  1. NR_104358.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC162614, AK007372, BB856072, BE854983, BY196593

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25358578..25367457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRA8.1 GenPept UniProtKB/Swiss-Prot:Q9CRA8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous