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Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 27137, updated on 13-Apr-2024

Summary

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Official Symbol
Eif2ak1provided by RGD
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 1provided by RGD
Primary source
RGD:70883
See related
Ensembl:ENSRNOG00000001050 AllianceGenome:RGD:70883
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hri
Summary
Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; negative regulation of hemoglobin biosynthetic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; protoporphyrinogen IX metabolic process; and regulation of cellular macromolecule biosynthetic process. Predicted to be located in cytoplasm. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 357.3), Adrenal (RPKM 259.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif2ak1 in Genome Data Viewer
Location:
12p11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15824431..15858266, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10710771..10744597, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12749026..12782078, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B Neighboring gene small nucleolar RNA SNORA51 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Neighboring gene ankyrin repeat domain 61 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 3 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene uncharacterized LOC134481266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression. Mellor H, et al. J Biol Chem, 1994 Apr 8. PMID 7908290
  2. Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. Han AP, et al. EMBO J, 2001 Dec 3. PMID 11726526, Free PMC Article
  3. Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase. Bauer BN, et al. Biochemistry, 2001 Sep 25. PMID 11560503
  4. Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase. Crosby JS, et al. Blood, 2000 Nov 1. PMID 11050009
  5. Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion. Rafie-Kolpin M, et al. J Biol Chem, 2000 Feb 18. PMID 10671563

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in HRI-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in HRI-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in HRI-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in acute inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within acute inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in integrated stress response signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in integrated stress response signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in macrophage differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organismal-level iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hemoglobin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protoporphyrinogen IX metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protoporphyrinogen IX metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of eIF2 alpha phosphorylation by heme IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to iron ion starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to iron ion starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to iron ion starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 2-alpha kinase 1
Names
HCR
heme-controlled repressor
heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
heme-regulated inhibitor
hemin-sensitive initiation factor 2-alpha kinase
hemin-sensitive initiation factor 2a kinase
NP_037355.2
XP_038945063.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013223.2 → NP_037355.2  eukaryotic translation initiation factor 2-alpha kinase 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q63185, Q642C7
    Related
    ENSRNOP00000001392.4, ENSRNOT00000001392.9
    Conserved Domains (1) summary
    cd14049
    Location:160 → 579
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15824431..15858266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089135.2 → XP_038945063.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K9K9
    Related
    ENSRNOP00000075036.1
    Conserved Domains (1) summary
    cd14049
    Location:160 → 604
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63185.2 GenPept UniProtKB/Swiss-Prot:Q63185

Gene LinkOut

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