CACYBP calcyclin binding protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: CACYBPprovided by HGNC
Official Full Name: calcyclin binding proteinprovided by HGNC
Primary source: HGNC:HGNC:30423
See related: Ensembl:ENSG00000116161 MIM:606186; AllianceGenome:HGNC:30423
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIP; GIG5; PNAS-107; S100A6BP
Summary: The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 20.4), ovary (RPKM 13.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q25.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (174999435..175012027)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (174353190..174365783)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (174968571..174981163)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CACYBP knockdown inhibits progression of prostate cancer via p53.
Title: CACYBP knockdown inhibits progression of prostate cancer via p53.
The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.
Title: The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.
Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.
Title: Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.
Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.
Title: Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.
Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and beta-Catenin Signaling.
Title: Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling.
[CacyBP promotes the proliferation and invasion of non-small cell lung cancer].
Title: [CacyBP promotes the proliferation and invasion of non-small cell lung cancer].
HSP90 Co-Chaperone, CacyBP/SIP, Protects alpha-Synuclein from Aggregation.
Title: HSP90 Co-Chaperone, CacyBP/SIP, Protects α-Synuclein from Aggregation.
CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.
Title: CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.
promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation
Title: SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
ur results show for the first time that CacyBP/SIP binds to and affects the properties of a nuclear protein, NPM1, and that it is indispensable for preserving the structure of nucleoli under oxidative stress.
Title: Interaction of CacyBP/SIP with NPM1 and its influence on NPM1 localization and function in oxidative stress.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of calcyclin binding protein (CACYBP) in the nucleoli of Jurkat T-cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-86290 (e-PCR)
- UniSTS:104509

SHGC-31968 (e-PCR)
- UniSTS:328

D1S2592 (e-PCR)
- UniSTS:55381

RH64562 (e-PCR)
- UniSTS:56692

SHGC-64074 (e-PCR)
- UniSTS:78455

SHGC-75931 (e-PCR)
- UniSTS:38304

CACYBP (e-PCR)
- UniSTS:503743

SHGC-75932 (e-PCR)
- UniSTS:29889

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables S100 protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin destruction complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in nuclear envelope lumen	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcyclin-binding protein

Names: S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein; hCacyBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029961.2 RefSeqGene

Range

5514..17594

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001007214.1 → NP_001007215.1 calcyclin-binding protein isoform 2

See identical proteins and their annotated locations for NP_001007215.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' exon, and uses a downstream AUG start codon, as compared to variant 1. The encoded isoform 2 has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AK093425, AL035305, AW300675, BQ432793

Consensus CDS

CCDS30942.1

UniProtKB/TrEMBL

Q6NVY0

Related

ENSP00000479414.1, ENST00000613570.4

Conserved Domains (3) summary

cd06468
Location:32 → 124

p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...

pfam05002
Location:139 → 174

SGS; SGS domain

pfam09032
Location:3 → 32

Siah-Interact_N; Siah interacting protein, N terminal
NM_014412.3 → NP_055227.1 calcyclin-binding protein isoform 1

See identical proteins and their annotated locations for NP_055227.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL035305, AW300675, CA951015

Consensus CDS

CCDS1315.1

UniProtKB/Swiss-Prot

B2ZWH2, B3KSF1, O60666, Q5R370, Q5R371, Q9HB71

UniProtKB/TrEMBL

Q6NVY0

Related

ENSP00000356652.2, ENST00000367679.7

Conserved Domains (3) summary

cd06468
Location:75 → 167

p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...

pfam05002
Location:182 → 217

SGS; SGS domain

pfam09032
Location:4 → 75

Siah-Interact_N; Siah interacting protein, N terminal