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UL44 envelope glycoprotein C [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703410, updated on 20-Nov-2023

Summary

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Gene symbol
UL44
Gene description
envelope glycoprotein C
Locus tag
HHV1gp00p31
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (96312..98669)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene DNA polymerase processivity subunit Neighboring gene envelope protein UL43 Neighboring gene membrane protein UL45 Neighboring gene tegument protein VP11/12 Neighboring gene tegument protein VP13/14 Neighboring gene transactivating tegument protein VP16

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of an ICP27-responsive element in the coding region of a herpes simplex virus type 1 late gene. Sedlackova L, et al. J Virol, 2010 Mar. PMID 20042503, Free PMC Article
  2. Heparan sulfate mediates cell uptake of αB-crystallin fused to the glycoprotein C cell penetration peptide. Droho S, et al. Biochim Biophys Acta Mol Cell Res, 2018 Apr. PMID 29408057
  3. Blocking antibody access to neutralizing domains on glycoproteins involved in entry as a novel mechanism of immune evasion by herpes simplex virus type 1 glycoproteins C and E. Hook LM, et al. J Virol, 2008 Jul. PMID 18480440, Free PMC Article
  4. Herpes simplex virus type 1-encoded glycoprotein C contributes to direct coagulation factor X-virus binding. Livingston JR, et al. Biochem J, 2006 Jan 15. PMID 16212554, Free PMC Article
  5. Herpes simplex virus type 1-encoded glycoprotein C enhances coagulation factor VIIa activity on the virus. Sutherland MR, et al. Thromb Haemost, 2004 Nov. PMID 15543320

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heparan sulfate mediates cell uptake of alphaB-crystallin fused to the glycoprotein C cell penetration peptide
    Title: Heparan sulfate mediates cell uptake of αB-crystallin fused to the glycoprotein C cell penetration peptide.
  2. Data suggest that the ICP27-independent gC expression occurred even in the absence of viral DNA synthesis, indicating that the silencing element helps to regulate the tight DNA replication-dependent expression of gC.
    Title: Identification of an ICP27-responsive element in the coding region of a herpes simplex virus type 1 late gene.
  3. gC and gE on WT virus provide a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL, or gD-gH/gL interactions and that one function of virus neutralization is to prevent interactions between these glycoproteins.
    Title: Blocking antibody access to neutralizing domains on glycoproteins involved in entry as a novel mechanism of immune evasion by herpes simplex virus type 1 glycoproteins C and E.
  4. data demonstrate that gC constitutes one type of direct FX-HSV1 interaction, possibly providing a molecular basis for clinical correlations between recurrent infection and vascular pathology
    Title: Herpes simplex virus type 1-encoded glycoprotein C contributes to direct coagulation factor X-virus binding.
  5. Two pathways initiating FX activation function in parallel on the virus surface. In addition to the previously described TF-dependent pathway, HSV-1-encoded gC also enhances FXa generation, and like TF, requires FVIIa.
    Title: Herpes simplex virus type 1-encoded glycoprotein C enhances coagulation factor VIIa activity on the virus.
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Pathways from PubChem

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General gene information

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Homology

regulatory

  • Loc: 98664-98669 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
envelope glycoprotein C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    96312..98669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137119.1 envelope glycoprotein C [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137119.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P10228
    UniProtKB/TrEMBL
    A0A181ZGL5, A0A2Z4HDS2, G8H8G5, G8HBF8, Q8UYE2, Q8UYF2
    Conserved Domains (1) summary
    PHA03270
    Location:1 → 511
    PHA03270; envelope glycoprotein C; Provisional
Nucleotide Protein
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