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Eif4e2 eukaryotic translation initiation factor 4E member 2 [ Mus musculus (house mouse) ]

Gene ID: 26987, updated on 11-Apr-2024

Summary

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Official Symbol
Eif4e2provided by MGI
Official Full Name
eukaryotic translation initiation factor 4E member 2provided by MGI
Primary source
MGI:MGI:1914440
See related
Ensembl:ENSMUSG00000026254 AllianceGenome:MGI:1914440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4el3; D0H0S6743E; 2700069E09Rik
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity; translation initiation factor activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in P-body. Predicted to be part of eukaryotic translation initiation factor 4F complex and mRNA cap binding activity complex. Is expressed in early conceptus; embryo; primary oocyte; and secondary oocyte. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.5), placenta adult (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C5; 1 44.08 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87141633..87168210)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87213911..87240488)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene cholinergic receptor, nicotinic, gamma polypeptide Neighboring gene STARR-seq mESC enhancer starr_01608 Neighboring gene STARR-seq mESC enhancer starr_01609 Neighboring gene predicted gene, 53571 Neighboring gene predicted gene, 26187 Neighboring gene EF hand domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_01611 Neighboring gene predicted gene, 41911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP. Wiebe S, et al. Mol Brain, 2023 Jan 18. PMID 36650535, Free PMC Article
  2. The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior. Wiebe S, et al. Mol Autism, 2020 Nov 23. PMID 33225984, Free PMC Article
  3. Cap-binding protein 4EHP effects translation silencing by microRNAs. Chapat C, et al. Proc Natl Acad Sci U S A, 2017 May 23. PMID 28487484, Free PMC Article
  4. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. von Stechow L, et al. Mol Cell Biol, 2015 Apr. PMID 25624349, Free PMC Article
  5. Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation. Villaescusa JC, et al. PLoS One, 2009. PMID 19365557, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
    Title: Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
  2. The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.
    Title: The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.
  3. microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
    Title: microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
  4. DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with Eif4e2. In turn, this causes Eif4e2 recruitment to the mRNA cap, where it is known to compete with eIF4E.
    Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
  5. Data show that Prep1 and 4EHP co-localize in the cytosol of growing mouse oocytes, and that Prep1 binds the Hoxb4 3'UTR to inhibit its translation.[4EHP]
    Title: Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA cap binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4E type 2
Names
eIF-4E type 2
eIF4E type 2
eIF4E-2
eIF4E-like protein 4E-LP
eukaryotic translation initiation factor 4E like 3
mRNA cap-binding protein type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039169.1 → NP_001034258.1  eukaryotic translation initiation factor 4E type 2 isoform 2

    See identical proteins and their annotated locations for NP_001034258.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC102611, AK017221
    Consensus CDS
    CCDS15131.1
    UniProtKB/TrEMBL
    D3Z730, Q0P688
    Related
    ENSMUSP00000108857.4, ENSMUST00000113231.4
    Conserved Domains (1) summary
    pfam01652
    Location:50 → 208
    IF4E; Eukaryotic initiation factor 4E

  2. NM_001039170.1 → NP_001034259.1  eukaryotic translation initiation factor 4E type 2 isoform 1

    See identical proteins and their annotated locations for NP_001034259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC102611, AK032965
    Consensus CDS
    CCDS35652.1
    UniProtKB/Swiss-Prot
    O88503, Q3UCK2, Q8BMB3
    UniProtKB/TrEMBL
    Q3UUT0
    Related
    ENSMUSP00000108859.2, ENSMUST00000113233.8
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 213
    IF4E; Eukaryotic initiation factor 4E

  3. NM_001347083.1 → NP_001334012.1  eukaryotic translation initiation factor 4E type 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102611
    Consensus CDS
    CCDS83571.1
    UniProtKB/TrEMBL
    D3Z729, Q3UUT0
    Related
    ENSMUSP00000108861.2, ENSMUST00000113235.8
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 213
    IF4E; Eukaryotic initiation factor 4E

  4. NM_023314.3 → NP_075803.2  eukaryotic translation initiation factor 4E type 2 isoform 3

    See identical proteins and their annotated locations for NP_075803.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3'-most exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC102611, AK032965, AK076067
    Consensus CDS
    CCDS15130.1
    UniProtKB/TrEMBL
    G3X9H1, Q9D334
    Related
    ENSMUSP00000075699.6, ENSMUST00000076362.12
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 213
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87141633..87168210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165581.1 → XP_036021474.1  eukaryotic translation initiation factor 4E type 2 isoform X1

    UniProtKB/TrEMBL
    Q9D334
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 214
    IF4E; Eukaryotic initiation factor 4E

  2. XM_036165586.1 → XP_036021479.1  eukaryotic translation initiation factor 4E type 2 isoform X3

    UniProtKB/TrEMBL
    Q9D334
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 214
    IF4E; Eukaryotic initiation factor 4E

  3. XM_006529674.4 → XP_006529737.1  eukaryotic translation initiation factor 4E type 2 isoform X7

    UniProtKB/TrEMBL
    D3YUV9, Q80ZJ3
    Related
    ENSMUSP00000053403.8, ENSMUST00000050876.14
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 214
    IF4E; Eukaryotic initiation factor 4E

  4. XM_030254746.1 → XP_030110606.1  eukaryotic translation initiation factor 4E type 2 isoform X5

    UniProtKB/TrEMBL
    Q9D334
    Conserved Domains (1) summary
    pfam01652
    Location:50 → 209
    IF4E; Eukaryotic initiation factor 4E

  5. XM_030254745.1 → XP_030110605.1  eukaryotic translation initiation factor 4E type 2 isoform X4

    UniProtKB/TrEMBL
    D3Z730
    Conserved Domains (1) summary
    pfam01652
    Location:50 → 209
    IF4E; Eukaryotic initiation factor 4E

  6. XM_036165583.1 → XP_036021476.1  eukaryotic translation initiation factor 4E type 2 isoform X2

    UniProtKB/TrEMBL
    Q9D334
    Conserved Domains (1) summary
    pfam01652
    Location:50 → 209
    IF4E; Eukaryotic initiation factor 4E

  7. XM_036165589.1 → XP_036021482.1  eukaryotic translation initiation factor 4E type 2 isoform X6

    UniProtKB/TrEMBL
    D3Z730
    Conserved Domains (1) summary
    pfam01652
    Location:50 → 209
    IF4E; Eukaryotic initiation factor 4E

RNA

  1. XR_004942584.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMB3.1 GenPept UniProtKB/Swiss-Prot:Q8BMB3

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