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Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma [ Mus musculus (house mouse) ]

Gene ID: 269643, updated on 16-Apr-2024

Summary

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Official Symbol
Ppp2r2cprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B, gammaprovided by MGI
Primary source
MGI:MGI:2442660
See related
Ensembl:ENSMUSG00000029120 AllianceGenome:MGI:2442660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR52; IMYPNO; IMYPNO1; 6330548O06Rik
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Is expressed in inner cell mass; pelvic ganglion; urethra of female; and urethra of male. Orthologous to human PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 105.0), frontal lobe adult (RPKM 88.2) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 19.28 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (37024187..37112422)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36866846..36955078)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Morf4 family associated protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:37221807-37222107 Neighboring gene mannosidase 2, alpha B2 Neighboring gene predicted gene, 52812 Neighboring gene protein phosphatase 2, regulatory subunit B, gamma, opposite strand Neighboring gene STARR-seq mESC enhancer starr_12887 Neighboring gene STARR-seq mESC enhancer starr_12890 Neighboring gene predicted gene, 52813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37370903-37371090 Neighboring gene STARR-positive B cell enhancer ABC_E6324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37380607-37380790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37389242-37389505 Neighboring gene STARR-seq mESC enhancer starr_12893 Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37436048-37436298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37438571-37438789 Neighboring gene janus kinase and microtubule interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37442129-37442330 Neighboring gene isocitrate dehydrogenase 3 (NAD+) beta pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice. Leong W, et al. Aging (Albany NY), 2020 Apr 14. PMID 32291379, Free PMC Article
  2. Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function. Zhang Y, et al. Am J Physiol Renal Physiol, 2016 Jan 15. PMID 26290374, Free PMC Article
  3. PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development. Sents W, et al. Cancer Res, 2017 Dec 15. PMID 29046336
  4. Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development. O'Shaughnessy RF, et al. Development, 2009 Oct. PMID 19762425, Free PMC Article
  5. Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration. Tao G, et al. Front Mol Neurosci, 2019. PMID 31001083, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice.
    Title: PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
NP_001346932.1
NP_766582.1
XP_006504034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360003.1 → NP_001346932.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC115722, AC169036
    Conserved Domains (2) summary
    COG5170
    Location:8 → 424
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:13 → 61
    7WD40; WD40 repeat [structural motif]

  2. NM_172994.4 → NP_766582.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1

    See identical proteins and their annotated locations for NP_766582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC115722, AC169036
    Consensus CDS
    CCDS19244.1
    UniProtKB/Swiss-Prot
    Q8BG02
    Related
    ENSMUSP00000031003.8, ENSMUST00000031003.11
    Conserved Domains (3) summary
    COG5170
    Location:21 → 438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 75
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:15 → 366
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    37024187..37112422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503971.4 → XP_006504034.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1

    Conserved Domains (2) summary
    COG5170
    Location:75 → 490
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:79 → 127
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG02.1 GenPept UniProtKB/Swiss-Prot:Q8BG02

Gene LinkOut

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