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Epb41 erythrocyte membrane protein band 4.1 [ Mus musculus (house mouse) ]

Gene ID: 269587, updated on 11-Apr-2024

Summary

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Official Symbol
Epb41provided by MGI
Official Full Name
erythrocyte membrane protein band 4.1provided by MGI
Primary source
MGI:MGI:95401
See related
Ensembl:ENSMUSG00000028906 AllianceGenome:MGI:95401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4.1R; Elp1; Elp-1; Epb4.1; mKIAA4056; D4Ertd442e
Summary
Predicted to enable several functions, including 1-phosphatidylinositol binding activity; cytoskeletal protein binding activity; and protein C-terminus binding activity. Involved in regulation of calcium ion transport and regulation of intestinal absorption. Acts upstream of or within positive regulation of protein binding activity. Located in basolateral plasma membrane and cortical cytoskeleton. Is expressed in several structures, including alimentary system; brain; connective tissue; eye; and genitourinary system. Used to study hereditary elliptocytosis. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 23.5), liver E14 (RPKM 23.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 64.54 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131650724..131802824, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131923413..132075346, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene serine and arginine-rich splicing factor 4 Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene Neighboring gene transmembrane protein 200B Neighboring gene VISTA enhancer mm1387 Neighboring gene STARR-positive B cell enhancer ABC_E4674 Neighboring gene predicted gene, 36157 Neighboring gene VISTA enhancer mm80 Neighboring gene STARR-positive B cell enhancer ABC_E3518 Neighboring gene STARR-seq mESC enhancer starr_11553 Neighboring gene STARR-seq mESC enhancer starr_11554 Neighboring gene opioid receptor, delta 1 Neighboring gene nuclear encoded tRNA alanine 3 (anticodon CGC) Neighboring gene predicted gene 13215

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid. Li B, et al. Exp Cell Res, 2021 Feb 15. PMID 33385415
  2. Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction. Ding C, et al. Exp Cell Res, 2021 Jan 15. PMID 33271128
  3. Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway. Liang T, et al. Immunology, 2020 Dec. PMID 32852059, Free PMC Article
  4. Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells. Zhao Q, et al. Med Sci Monit, 2020 Mar 11. PMID 32157074, Free PMC Article
  5. Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells. Draberova L, et al. Front Immunol, 2019. PMID 31993060, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis.
    Title: The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis.
  2. Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation.
    Title: Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation.
  3. Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid.
    Title: Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid.
  4. Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-kappaB pathway.
    Title: Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway.
  5. Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction.
    Title: Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction.
  6. Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.
    Title: Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.
  7. Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcepsilonRI Signaling and Chemotaxis in Mast Cells.
    Title: Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.
  8. The role of 4.1R in the regulation of EGFR signaling in keratinocytes.
    Title: Cytoskeleton protein 4.1R suppresses murine keratinocyte cell hyperproliferation via activating the Akt/ERK pathway in an EGFR-dependent manner.
  9. These data enabled the identification of a negative regulation function for 4.1R in CD8(+) T cells by a direct association between 4.1R and LAT, possibly through inhibiting phosphorylation of LAT and then modulating intracellular signal transduction.
    Title: Protein 4.1R negatively regulates CD8(+) T-cell activation by modulating phosphorylation of linker for activation of T cells.
  10. Formation of an erythroid-specific, protein 4.1R-dependent membrane skeleton is an important feature not only of definitive, but also of primitive, erythropoiesis in mammals.
    Title: Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4056

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables spectrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of intestinal absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein 4.1
Names
P4.1
Protein 4.1R
band 4.1
erythrocyte protein band 4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128606.1 → NP_001122078.1  protein 4.1 isoform 2

    See identical proteins and their annotated locations for NP_001122078.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple in-frame exons and uses a different 5' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK220462, CA324069
    Consensus CDS
    CCDS51317.1
    UniProtKB/TrEMBL
    A2A842
    Related
    ENSMUSP00000081274.4, ENSMUST00000084253.10
    Conserved Domains (7) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:297 → 402
    FERM_M; FERM central domain
    pfam04382
    Location:609 → 653
    SAB; SAB domain
    pfam05902
    Location:694 → 800
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 542
    FA; FERM adjacent (FA)
    pfam09379
    Location:215 → 275
    FERM_N; FERM N-terminal domain

  2. NM_001128607.2 → NP_001122079.1  protein 4.1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple in-frame exons, uses an alternate 5' splice site, and uses a different 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream ATG and an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AL607088, AL669981
    Consensus CDS
    CCDS89834.1
    UniProtKB/TrEMBL
    A0A571BEG4, A2A838
    Related
    ENSMUSP00000158714.2, ENSMUST00000146021.8
    Conserved Domains (7) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:87 → 192
    FERM_M; FERM central domain
    pfam04382
    Location:399 → 443
    SAB; SAB domain
    pfam05902
    Location:484 → 590
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)
    pfam09379
    Location:5 → 65
    FERM_N; FERM N-terminal domain

  3. NM_183428.3 → NP_906273.3  protein 4.1 isoform 1

    See identical proteins and their annotated locations for NP_906273.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK220462, AL669981, CB526050, CB723734, CN526385, CN537562
    Consensus CDS
    CCDS18717.1
    UniProtKB/Swiss-Prot
    A2A843, P48193, Q5DTQ8, Q68FF1, Q6NVF5
    UniProtKB/TrEMBL
    A2A841
    Related
    ENSMUSP00000030739.5, ENSMUST00000030739.11
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:662 → 709
    SAB; SAB domain
    pfam05902
    Location:748 → 854
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 542
    FA; FERM adjacent (FA)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131650724..131802824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320238.3 → XP_017175727.1  protein 4.1 isoform X12

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:399 → 445
    SAB; SAB domain
    pfam05902
    Location:634 → 740
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  2. XM_036164149.1 → XP_036020042.1  protein 4.1 isoform X24

    UniProtKB/TrEMBL
    A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:399 → 445
    SAB; SAB domain
    pfam05902
    Location:496 → 602
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 333
    FA; FERM adjacent (FA)

  3. XM_006538901.5 → XP_006538964.2  protein 4.1 isoform X10

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:399 → 445
    SAB; SAB domain
    pfam05902
    Location:651 → 757
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  4. XM_017320241.3 → XP_017175730.1  protein 4.1 isoform X23

    UniProtKB/TrEMBL
    A0A068WAZ7, A2A838
    Related
    ENSMUSP00000123623.2, ENSMUST00000137846.8
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:419 → 466
    SAB; SAB domain
    pfam05902
    Location:505 → 611
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  5. XM_017320237.3 → XP_017175726.1  protein 4.1 isoform X9

    UniProtKB/TrEMBL
    A0A068WAQ5, A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:419 → 466
    SAB; SAB domain
    pfam05902
    Location:655 → 761
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  6. XM_036164147.1 → XP_036020040.1  protein 4.1 isoform X21

    UniProtKB/TrEMBL
    A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:418 → 466
    SAB; SAB domain
    pfam05902
    Location:517 → 623
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 333
    FA; FERM adjacent (FA)

  7. XM_036164143.1 → XP_036020036.1  protein 4.1 isoform X8

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:418 → 466
    SAB; SAB domain
    pfam05902
    Location:667 → 773
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 333
    FA; FERM adjacent (FA)

  8. XM_006538899.5 → XP_006538962.2  protein 4.1 isoform X6

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:419 → 466
    SAB; SAB domain
    pfam05902
    Location:672 → 778
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  9. XM_006538910.5 → XP_006538973.2  protein 4.1 isoform X20

    UniProtKB/TrEMBL
    A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:433 → 480
    SAB; SAB domain
    pfam05902
    Location:519 → 625
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  10. XM_006538909.5 → XP_006538972.2  protein 4.1 isoform X19

    UniProtKB/TrEMBL
    A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:438 → 485
    SAB; SAB domain
    pfam05902
    Location:524 → 630
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  11. XM_006538896.5 → XP_006538959.2  protein 4.1 isoform X4

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:438 → 485
    SAB; SAB domain
    pfam05902
    Location:691 → 797
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  12. XM_006538908.5 → XP_006538971.2  protein 4.1 isoform X17

    UniProtKB/TrEMBL
    A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:452 → 499
    SAB; SAB domain
    pfam05902
    Location:538 → 644
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  13. XM_006538897.5 → XP_006538960.2  protein 4.1 isoform X5

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:452 → 499
    SAB; SAB domain
    pfam05902
    Location:688 → 794
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  14. XM_036164145.1 → XP_036020038.1  protein 4.1 isoform X16

    UniProtKB/TrEMBL
    A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:451 → 499
    SAB; SAB domain
    pfam05902
    Location:550 → 656
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 333
    FA; FERM adjacent (FA)

  15. XM_006538895.5 → XP_006538958.2  protein 4.1 isoform X3

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:452 → 499
    SAB; SAB domain
    pfam05902
    Location:700 → 806
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  16. XM_006538893.5 → XP_006538956.2  protein 4.1 isoform X1

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:452 → 499
    SAB; SAB domain
    pfam05902
    Location:705 → 811
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  17. XM_006538912.5 → XP_006538975.2  protein 4.1 isoform X25

    UniProtKB/TrEMBL
    A2A838
    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:398 → 444
    SAB; SAB domain
    pfam05902
    Location:483 → 589
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  18. XM_006538902.5 → XP_006538965.2  protein 4.1 isoform X11

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:398 → 444
    SAB; SAB domain
    pfam05902
    Location:650 → 756
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  19. XM_006538900.5 → XP_006538963.2  protein 4.1 isoform X7

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:418 → 465
    SAB; SAB domain
    pfam05902
    Location:671 → 777
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  20. XM_006538894.5 → XP_006538957.2  protein 4.1 isoform X2

    Conserved Domains (5) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:451 → 498
    SAB; SAB domain
    pfam05902
    Location:704 → 810
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  21. XM_017320243.2 → XP_017175732.1  protein 4.1 isoform X36

    UniProtKB/TrEMBL
    A2A842
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:608 → 654
    SAB; SAB domain
    pfam05902
    Location:693 → 799
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 542
    FA; FERM adjacent (FA)

  22. XM_036164155.1 → XP_036020048.1  protein 4.1 isoform X35

    UniProtKB/TrEMBL
    B6ZHC8
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:627 → 675
    SAB; SAB domain
    pfam05902
    Location:714 → 820
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 543
    FA; FERM adjacent (FA)

  23. XM_036164151.1 → XP_036020044.1  protein 4.1 isoform X31

    UniProtKB/TrEMBL
    A2A841
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:660 → 708
    SAB; SAB domain
    pfam05902
    Location:747 → 853
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 543
    FA; FERM adjacent (FA)

  24. XM_036164144.1 → XP_036020037.1  protein 4.1 isoform X14

    UniProtKB/TrEMBL
    A2A841
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:660 → 708
    SAB; SAB domain
    pfam05902
    Location:914 → 1020
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 543
    FA; FERM adjacent (FA)

  25. XM_036164148.1 → XP_036020041.1  protein 4.1 isoform X22

    UniProtKB/TrEMBL
    B6ZHC8
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:609 → 655
    SAB; SAB domain
    pfam05902
    Location:844 → 950
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 543
    FA; FERM adjacent (FA)

  26. XM_036164146.1 → XP_036020039.1  protein 4.1 isoform X18

    UniProtKB/TrEMBL
    B6ZHC8
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:609 → 655
    SAB; SAB domain
    pfam05902
    Location:861 → 967
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 543
    FA; FERM adjacent (FA)

  27. XM_036164154.1 → XP_036020047.1  protein 4.1 isoform X34

    UniProtKB/TrEMBL
    B6ZHC8
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:628 → 676
    SAB; SAB domain
    pfam05902
    Location:715 → 821
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 543
    FA; FERM adjacent (FA)

  28. XM_030253586.2 → XP_030109446.1  protein 4.1 isoform X30

    UniProtKB/Swiss-Prot
    A2A843, P48193, Q5DTQ8, Q68FF1, Q6NVF5
    UniProtKB/TrEMBL
    A2A841
    Related
    ENSMUSP00000101601.3, ENSMUST00000105981.9
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:662 → 709
    SAB; SAB domain
    pfam05902
    Location:748 → 854
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 542
    FA; FERM adjacent (FA)

  29. XM_006538907.5 → XP_006538970.1  protein 4.1 isoform X13

    UniProtKB/TrEMBL
    A2A841
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:662 → 709
    SAB; SAB domain
    pfam05902
    Location:915 → 1021
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 542
    FA; FERM adjacent (FA)

  30. XM_017320239.1 → XP_017175728.1  protein 4.1 isoform X15

    UniProtKB/TrEMBL
    A2A841
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:648 → 695
    SAB; SAB domain
    pfam05902
    Location:901 → 1007
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 542
    FA; FERM adjacent (FA)

  31. XM_036164150.1 → XP_036020043.1  protein 4.1 isoform X29

    UniProtKB/TrEMBL
    A2A841
    Conserved Domains (5) summary
    smart00295
    Location:212 → 402
    B41; Band 4.1 homologues
    cd13184
    Location:397 → 490
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:661 → 709
    SAB; SAB domain
    pfam05902
    Location:760 → 866
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:500 → 543
    FA; FERM adjacent (FA)

  32. XM_036164152.1 → XP_036020045.1  protein 4.1 isoform X32

    Conserved Domains (4) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:399 → 445
    SAB; SAB domain
    pfam08736
    Location:290 → 333
    FA; FERM adjacent (FA)

  33. XM_006538916.5 → XP_006538979.2  protein 4.1 isoform X28

    Conserved Domains (4) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:452 → 499
    SAB; SAB domain
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  34. XM_006538915.5 → XP_006538978.2  protein 4.1 isoform X27

    Conserved Domains (4) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:452 → 499
    SAB; SAB domain
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  35. XM_006538913.5 → XP_006538976.2  protein 4.1 isoform X26

    Conserved Domains (4) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:452 → 499
    SAB; SAB domain
    pfam08736
    Location:290 → 332
    FA; FERM adjacent (FA)

  36. XM_036164153.1 → XP_036020046.1  protein 4.1 isoform X33

    Conserved Domains (4) summary
    smart00295
    Location:2 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:398 → 444
    SAB; SAB domain
    pfam08736
    Location:290 → 333
    FA; FERM adjacent (FA)

  37. XM_036164159.1 → XP_036020052.1  protein 4.1 isoform X40

    UniProtKB/TrEMBL
    A2AD32
    Conserved Domains (4) summary
    smart00295
    Location:222 → 412
    B41; Band 4.1 homologues
    cd13184
    Location:407 → 500
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:670 → 718
    SAB; SAB domain
    pfam08736
    Location:510 → 553
    FA; FERM adjacent (FA)

  38. XM_036164157.1 → XP_036020050.1  protein 4.1 isoform X38

    UniProtKB/TrEMBL
    A2AD32
    Conserved Domains (4) summary
    smart00295
    Location:222 → 412
    B41; Band 4.1 homologues
    cd13184
    Location:407 → 500
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:670 → 718
    SAB; SAB domain
    pfam08736
    Location:510 → 553
    FA; FERM adjacent (FA)

  39. XM_036164160.1 → XP_036020053.1  protein 4.1 isoform X41

    UniProtKB/TrEMBL
    A2AD32
    Conserved Domains (4) summary
    smart00295
    Location:222 → 412
    B41; Band 4.1 homologues
    cd13184
    Location:407 → 500
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:619 → 665
    SAB; SAB domain
    pfam08736
    Location:510 → 553
    FA; FERM adjacent (FA)

  40. XM_036164158.1 → XP_036020051.1  protein 4.1 isoform X39

    UniProtKB/TrEMBL
    A2AD32
    Conserved Domains (4) summary
    smart00295
    Location:222 → 412
    B41; Band 4.1 homologues
    cd13184
    Location:407 → 500
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:671 → 719
    SAB; SAB domain
    pfam08736
    Location:510 → 553
    FA; FERM adjacent (FA)

  41. XM_036164156.1 → XP_036020049.1  protein 4.1 isoform X37

    UniProtKB/TrEMBL
    A2AD32
    Related
    ENSMUSP00000120236.3, ENSMUST00000141291.3
    Conserved Domains (4) summary
    smart00295
    Location:222 → 412
    B41; Band 4.1 homologues
    cd13184
    Location:407 → 500
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:671 → 719
    SAB; SAB domain
    pfam08736
    Location:510 → 553
    FA; FERM adjacent (FA)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48193.2 GenPept UniProtKB/Swiss-Prot:P48193

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