Ahcy S-adenosylhomocysteine hydrolase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ahcyprovided by MGI
Official Full Name: S-adenosylhomocysteine hydrolaseprovided by MGI
Primary source: MGI:MGI:87968
See related: Ensembl:ENSMUSG00000027597 AllianceGenome:MGI:87968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CuBP; SAHH
Summary: Enables adenosylhomocysteinase activity; copper ion binding activity; and protein self-association. Acts upstream of or within S-adenosylhomocysteine catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 623.2), liver E18 (RPKM 163.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 76.94 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (154901230..154916417, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (155059310..155074497, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenosylhomocysteinase plays multiple roles in maintaining the identity and pluripotency of mouse embryonic stem cellsdagger.
Title: Adenosylhomocysteinase plays multiple roles in maintaining the identity and pluripotency of mouse embryonic stem cells†.
Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells.
Title: Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells.
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Title: Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling.
Title: S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling.
Inhibition of DJ-1 potently enhances the sensitivity of tumor cells to ferroptosis inducers both in vitro and in vivo. Metabolic analysis and metabolite rescue assay reveal that DJ-1 depletion inhibits the transsulfuration pathway by disrupting the formation of the S-adenosyl homocysteine hydrolase tetramer and impairing its activity. Study findings show that DJ-1 determines the response of cancer cells to ferroptosis.
Title: DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase.
These results indicate that epigenetically mediated inhibition of Ahcy expression may be a driving force in causing SAH elevation and subsequent downstream disturbances in transsulfuration and transmethylation pathways during the development and progression of nonalcoholic steatohepatitis.
Title: Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus.
Title: H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.
Title: Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution.
Title: Crystallization of mouse S-adenosyl-L-homocysteine hydrolase.
report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase.
Title: S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (4)
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA987153 (e-PCR)
- UniSTS:178747

Ahcy (e-PCR), detects polymorphism
- UniSTS:526032

RH125484 (e-PCR)
- UniSTS:162303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables adenosylhomocysteinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylhomocysteinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosylhomocysteinase activity	ISO Inferred from Sequence Orthology more info
enables adenyl nucleotide binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within S-adenosylhomocysteine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in S-adenosylhomocysteine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylmethionine cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in chronic inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in circadian sleep/wake cycle	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosylhomocysteinase

Names: S-adenosyl-L-homocysteine hydrolase; adoHcyase; liver copper-binding protein

NP_057870.3

EC 3.13.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.