Acvr1c activin A receptor, type IC [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acvr1cprovided by MGI
Official Full Name: activin A receptor, type ICprovided by MGI
Primary source: MGI:MGI:2661081
See related: Ensembl:ENSMUSG00000026834 AllianceGenome:MGI:2661081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ALK7; Alk-7; ACTR-IC; ACVRLK7; C230097P10
Summary: Predicted to enable several functions, including ATP binding activity; BMP receptor binding activity; and activin binding activity. Acts upstream of or within several processes, including negative regulation of insulin secretion; response to glucose; and response to insulin. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; brain; and genitourinary system. Orthologous to human ACVR1C (activin A receptor type 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 3.9), genital fat pad adult (RPKM 2.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 33.05 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (58157465..58247909, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (58267453..58357896, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders.
Title: Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders.
Regulation of metabolic homeostasis by the TGF-beta superfamily receptor ALK7.
Title: Regulation of metabolic homeostasis by the TGF-β superfamily receptor ALK7.
The orphan ligand, activin C, signals through activin receptor-like kinase 7.
Title: The orphan ligand, activin C, signals through activin receptor-like kinase 7.
Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7.
Title: Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7.
ALK7 Promotes Vascular Smooth Muscle Cells Phenotypic Modulation by Negative Regulating PPARgamma Expression.
Title: ALK7 Promotes Vascular Smooth Muscle Cells Phenotypic Modulation by Negative Regulating PPARγ Expression.
Data, including data from studies using knockout mice, suggest that Gdf3-Alk7 axis between adipose tissue macrophages and adipocytes represents previously unrecognized mechanism by which insulin regulates both fat metabolism/lipolysis and adiposity. (Gdf3 = growth differentiation factor-3; Alk7 = activin receptor-like kinase-7)
Title: Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages.
Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax.
Title: Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
ALK7 protects against pathological cardiac hypertrophy in mice.
Title: ALK7 protects against pathological cardiac hypertrophy in mice.
These findings suggest that endogenous expression of ALK7 is necessary to maintain repolarizing K+ currents in ventricular cardiomyocytes, and finally prevent action potential prolongation and ventricular arrhythmia.
Title: Alk7 Depleted Mice Exhibit Prolonged Cardiac Repolarization and Are Predisposed to Ventricular Arrhythmia.
ALK7 signaling contributes to diet-induced catecholamine resistance in adipose tissue; ALK7 inhibitors may have therapeutic value in human obesity.
Title: Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF390693 (e-PCR)
- UniSTS:249524

Acvr1c (e-PCR), detects polymorphism
- UniSTS:496630

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
NOT enables activin binding	ISO Inferred from Sequence Orthology more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables activin receptor activity	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nodal binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic nuclear changes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chorionic trophoblast cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nodal signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophectodermal cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: activin receptor type-1C

Names: activin receptor type IC; activin receptor-like kinase 7

NP_001028541.1

EC 2.7.11.30

NP_001104500.1

EC 2.7.11.30

XP_006498148.1

EC 2.7.11.30

XP_006498149.1

EC 2.7.11.30

XP_011237410.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033369.3 → NP_001028541.1 activin receptor type-1C isoform 2

See identical proteins and their annotated locations for NP_001028541.1

Status: VALIDATED

Source sequence(s)

AI643872, AK049089, AL772179

Consensus CDS

CCDS16049.1

UniProtKB/TrEMBL

B7ZNG1, Q3V348

Related

ENSMUSP00000097663.2, ENSMUST00000100085.8

Conserved Domains (3) summary

cd14143
Location:69 → 356

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:5 → 45

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:51 → 63

TGF_beta_GS; Transforming growth factor beta type I GS-motif
NM_001111030.1 → NP_001104500.1 activin receptor type-1C isoform 1 precursor

See identical proteins and their annotated locations for NP_001104500.1

Status: VALIDATED

Source sequence(s)

AI643872, AK142396, AL772179, BC028780

Consensus CDS

CCDS50586.1

UniProtKB/Swiss-Prot

A2AJR4, Q8K348

UniProtKB/TrEMBL

B7ZNG1

Related

ENSMUSP00000028178.8, ENSMUST00000028178.14

Conserved Domains (4) summary

cd14143
Location:199 → 486

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:27 → 100

Activin_recp; Activin types I and II receptor domain

pfam07714
Location:195 → 474

Pkinase_Tyr; Protein tyrosine kinase

pfam08515
Location:166 → 193

TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

58157465..58247909 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498086.5 → XP_006498149.1 activin receptor type-1C isoform X2

See identical proteins and their annotated locations for XP_006498149.1

UniProtKB/TrEMBL

A2AJR5, A2AJR6

Related

ENSMUSP00000108227.3, ENSMUST00000112608.9

Conserved Domains (3) summary

cd14143
Location:119 → 406

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:27 → 95

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:101 → 113

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_011239108.2 → XP_011237410.1 activin receptor type-1C isoform X1

See identical proteins and their annotated locations for XP_011237410.1

UniProtKB/TrEMBL

B7ZNG1

Conserved Domains (3) summary

cd14143
Location:149 → 436

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:1 → 45

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:116 → 143

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_006498085.5 → XP_006498148.1 activin receptor type-1C isoform X1

See identical proteins and their annotated locations for XP_006498148.1

UniProtKB/TrEMBL

B7ZNG1

Conserved Domains (3) summary

cd14143
Location:149 → 436

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:1 → 45

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:116 → 143

TGF_beta_GS; Transforming growth factor beta type I GS-motif